Phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in Korean water deer (Hydropotes inermis argyropus) in the Republic of Korea |
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| Institution: | 1. Environmental Health Research Department, National Institution of Environmental Research, Hwangyeong-ro 42, Seo-gu, Incheon, Republic of Korea;2. Department of Microbiology, College of Natural Sciences, Dankook University, Cheonan, 31116, Republic of Korea;1. Department of Viral Research, Ningbo Center of Disease Control and Prevention, Ningbo 315010, China;2. Department of Epidemiology, Second Military Medical University, Shanghai 200433, China;1. Laboratory of Veterinary Internal Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea;2. Department of Microbiology and Immunology, Seoul National University College of Medicine and Department of Biomedical Sciences, Seoul National University Medical Research Center, Seoul, 03080, Republic of Korea;3. Apple Animal Hospital, Chungju, 27359, Republic of Korea;4. College of Ecology and Environmental Science, Kyungpook National University, Sangju, 37224, Republic of Korea;1. Division of Arboviruses, Center for Immunology & Pathology, National Institute of Health, Korea Centers for Disease Control & Prevention, Republic of Korea;2. Division of Medical Entomology, Center for Immunology & Pathology, National Institute of Health, Korea Centers for Disease Control & Prevention, Republic of Korea;1. Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China;2. Clinical Laboratory, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, 210000, China;1. College of Life Science, Jilin Agricultural University, Changchun, China;2. Military Veterinary Institute, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China |
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| Abstract: | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic tick-borne disease caused by SFTS virus, which circulates among ticks and their host animals, including wildlife. However, few studies have examined SFTS virus infection in wildlife present in the Republic of Korea (ROK). We evaluated SFTS virus infection in tissue samples from Korean water deer (Hydropotes inermis argyropus), one of the most common wild ungulates in ROK. In this study, we evaluated tissue samples of 129 water deer carcasses collected in 2017 and detected SFTS viral RNA by conventional PCR. SFTS viral RNA was found in 3 of the 129 carcasses, showing a prevalence of 2.3 %; 2 of which were collected in Gyeongsangnam-do and 1 of which was in the Gangwon-do region. Among the 6 internal organs studied, only the spleen samples were positive. Phylogenetic analysis revealed close relationships between deer- and human-derived strains. The medium segments of the three positive cases clustered with genotype B, which is the predominant genotype in ROK. In the small segment, two cases clustered with genotype B, samples 17WD044 and 17WD065. The third sample, 17WD068 from Gangwon-do province, showed genotype A, which circulates mainly in China. The disagreement in the genotypes of the two tested segments suggests a potential reassortment between genotype A and B, resulting in genetic recombination as observed in sample 17WD068, which may be co-circulating in China and Korea. Further studies in wildlife and humans are necessary to understand the genetic characteristics of SFTS viruses circulating in ROK. |
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| Keywords: | Severe fever with thrombocytopenia syndrome virus Wildlife Tick-borne pathogens Republic of Korea |
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