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Dietary Flavonoids and Gastric Cancer Risk in a Korean Population
Authors:Hae Dong Woo  Jeonghee Lee  Il Ju Choi  Chan Gyoo Kim  Jong Yeul Lee  Oran Kwon  Jeongseon Kim
Institution:1.Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Gyeonggi-do 410-769, Korea; E-Mails: (H.D.W.); (J.L.);2.Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do 410-769, Korea; E-Mails: (I.J.C.); (C.G.K.); (J.Y.L.);3.Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea; E-Mail:
Abstract:Gastric cancer is the most common cancer among men in Korea, and dietary factors are closely associated with gastric cancer risk. We performed a case-control study using 334 cases and 334 matched controls aged 35–75 years. Significant associations were observed in total dietary flavonoids and their subclasses, with the exception of anthocyanidins and isoflavones (OR (95% CI): 0.49 (0.31–0.76), p trend = 0.007 for total flavonoids). However, these associations were not significant after further adjustment for fruits and vegetable consumption (OR (95% CI): 0.62 (0.36–1.09), p trend = 0.458 for total flavonoids). Total flavonoids and their subclasses, except for isoflavones, were significantly associated with a reduced risk gastric cancer in women (OR (95% CI): 0.33 (0.15–0.73), p trend = 0.001 for total flavonoids) but not in men (OR (95% CI): 0.70 (0.39–1.24), p trend = 0.393 for total flavonoids). A significant inverse association with gastric cancer risk was observed in flavones, even after additional adjustment for fruits and vegetable consumption in women. No significantly different effects of flavonoids were observed between H. pylori-positive and negative subjects. In conclusion, dietary flavonoids were inversely associated with gastric cancer risk, and these protective effects of dietary flavonoids were prominent in women. No clear differences were observed in the subgroup analysis of H. pylori and smoking status.
Keywords:gastric cancer  flavonoids  H  pylori  smoking  case-control study
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