Charlson comorbidity index and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis |
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| Institution: | 1. Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar- Bali, Indonesia;2. RSUD Balaraja, Tangerang, Indonesia;3. Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia;4. Ken Saras General Hospital, Semarang, Indonesia;5. Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University Denpasar, Bali, Indonesia |
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| Abstract: | Background and aimsThe ongoing COVID-19 pandemic is disproportionately affecting patients with comorbidities. Therefore, thorough comorbidities assessment can help establish risk stratification of patients with COVID-19, upon hospital admission. Charlson Comorbidity Index (CCI) is a validated, simple, and readily applicable method of estimating the risk of death from comorbid disease and has been widely used as a predictor of long-term prognosis and survival.MethodsWe performed a systematic review and meta-analysis of CCI score and a composite of poor outcomes through several databases.ResultsCompared to a CCI score of 0, a CCI score of 1–2 and CCI score of ≥3 was prognostically associated with mortality and associated with a composite of poor outcomes. Per point increase of CCI score also increased mortality risk by 16%. Moreover, a higher mean CCI score also significantly associated with mortality and disease severity.ConclusionCCI score should be utilized for risk stratifications of hospitalized COVID-19 patients. |
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| Keywords: | Charlson comorbidity index COVID-19 Mortality Severity Mechanical ventilation |
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