CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel |
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| Authors: | Takashi Tokuda Masayuki Takahashi Kazuhiro Uejima Keita Masuda Toshikazu Kawamura Yasumi Ohta Mayumi Motoyama Toshihiko Noda Kiyotaka Sasagawa Teru Okitsu Shoji Takeuchi Jun Ohta |
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| Affiliation: | 1.Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan;2.TERUMO Co., R&D Headquarters, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan;3.Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan |
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| Abstract: | A CMOS image sensor-based implantable glucose sensor based on an optical-sensing scheme is proposed and experimentally verified. A glucose-responsive fluorescent hydrogel is used as the mediator in the measurement scheme. The wired implantable glucose sensor was realized by integrating a CMOS image sensor, hydrogel, UV light emitting diodes, and an optical filter on a flexible polyimide substrate. Feasibility of the glucose sensor was verified by both in vitro and in vivo experiments.OCIS codes: (000.0000) General, (000.2700) General science |
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