Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin. |
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Authors: | H C Fehmann R G?ke B G?ke |
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Affiliation: | Department of Internal Medicine, Philipps University of Marburg, Germany. |
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Abstract: | Glucagon-like peptide-1 (GLP-1) is the main product of the intestinal processing of proglucagon. It is released from the intestinal K-cells into the circulation in response to the oral ingestion of food. At the pancreatic beta cell GLP-1 is a potent insulin secretagogue in the presence of elevated glucose levels, defining glucagon-like peptide-1 as a new incretin. Its action is mediated by specific receptors coupled to the adenylate cyclase system by a stimulatory G-protein. Finally, glucagon-like peptide-1 stimulates proinsulin gene expression and it is thus involved at several levels in the regulation of insulin synthesis and secretion. |
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