| 骨代谢分子信号通路研究进展 |
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| 引用本文： | 刘中天,尚靖.骨代谢分子信号通路研究进展[J].亚太传统医药,2012,8(6):222-224. |
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| 作者姓名： | 刘中天 尚靖 |
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| 作者单位： | 中国药科大学,新药筛选中心,江苏,南京,210009 |
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| 摘 要： | 骨代谢异常可引起骨质疏松、佩吉特症、骨硬化症、骨折等疾病;其病因复杂,机理不明。骨代谢过程包括骨形成及骨吸收,其具体的分子调节通路不明。现代研究表明,在骨代谢过程中至少存在WNT/β-连环蛋白通路、NFAT通路、胰岛素信号通路、Sema4D-Plexin-B1通路、PI3K-AKT通路及MAPK通路等。通过分子信号通路,可有效促进骨代谢研究,并开发具有治疗骨代谢异常疾病的新药。
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| 关 键 词： | 骨代谢 WNT/β-连环蛋白通路 NFAT通路 胰岛素通路 Sema4D-Plexin-B1通路 PI3K-AKT通路MAPK通路 |
Signaling Pathways in Bone Metabolism |
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| Liu Zhongtian
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Shang Jing.Signaling Pathways in Bone Metabolism[J].Asia-Pacific Traditional Medicine,2012,8(6):222-224. |
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| Authors: | Liu Zhongtian Shang Jing |
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| Institution: | (New Drug Screening Center,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Bone metabolism disorders include osteoporosis、paget’s disease、osteopetrosis and bone fracture.The causes of these diseases is complicated.Bone remodeling process that involves bone synthesis and bone resorption,whose physiological mechanism is beyond our knowledge.Current researches dominate that at least six signaling pathways exist in bone remodeling process:Wnt/β-catenin signaling pathway,NFAT signaling pathway,insulin signaling pathway,Sema4D-Plexin-B1 signaling pathway,PI3K-AKT and MAPK signaling pathway.Through the pathways,people can know more about bone metabolism and find new drugs to treat bone disease.This work is a review about signaling pathways in bone metabolism. |
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| Keywords: | Bone Metabolism Wnt/β-catenin Signaling Pathway NFAT Signaling Pathway Insulin Signaling Pathway Sema4D-Plexin-B1 Signaling Pathway PI3K-AKT and MAPK Signaling Pathway |
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