| CD44v6及MMP-2在胆囊癌中的表达及其临床意义 |
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| 引用本文： | 吕小元,阳海红.CD44v6及MMP-2在胆囊癌中的表达及其临床意义[J].医学理论与实践,2012,25(7):760-762. |
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| 作者姓名： | 吕小元 阳海红 |
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| 作者单位： | 1. 邵阳医学高等专科学校,湖南省邵阳市,422000
2. 邵阳市中心医院 |
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| 摘 要： | 目的:探讨CD44v6和MMP-2在胆囊癌组织中的表达及其临床意义。方法:利用免疫组化法检测CD44v6和MMP-2在55例胆囊癌组织中及60例慢性胆囊炎和50例胆囊腺瘤组织中的表达,并结合临床病理资料进行分析。结果:55例胆囊癌患者CD44v6和MMP-2的阳性数分别为46例及41例,阳性率分别为83.64%,74.55%,远远高于慢性胆囊炎患者和胆囊腺瘤患者,同时与组织的分化及侵袭转移程度呈显著性相关。结论:CD44v6和MMP-2在胆囊癌组织中有较高的表达,与胆囊癌的发生,转移及预后有关。
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| 关 键 词： | CD44v6 MMP-2 胆囊癌 临床意义 |
CD44v6 and MMP-2 in Gallbladder Carcinoma and Its Clinical Significance |
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| LV Xiaoyuan
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YANG Haihong.CD44v6 and MMP-2 in Gallbladder Carcinoma and Its Clinical Significance[J].The Journal of Medical Theory and Practice,2012,25(7):760-762. |
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| Authors: | LV Xiaoyuan YANG Haihong |
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| Institution: | .Shaoyang Medicine College,Shaoyang City,Hunan Province 422000 |
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| Abstract: | Objective:Study of CD44v6 and MMP-2 in gallbladder carcinoma and its clinical significance.Methods:Using immunohistochemistry assay for detection of CD44v6 and MMP-2 in 55 cases of gallbladder carcinoma and 60 cases of chronic cholecystitis and 50 cases of biliary cystadenoma tissue expression,combined with clinical and pathological data analysis.Results:In 55 cases of gallbladder cancer in patients with CD44v6 and MMP-2 positive 46 cases and 41 cases respectively,the positive rate was 83.64%,74.55%,much higher than in patients with chronic cholecystitis and gallbladder adenoma patients,and tissue differentiation and invasion and metastasis of a significant correlation degree.Conclusion:CD44v6 and MMP-2 in gallbladder carcinoma tissue in a higher expression,and gallbladder cancer,metastasis and prognosis |
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| Keywords: | CD44v6 MMP-2 Gallbladder carcinoma Clinical significance |
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