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| 熊去氧胆酸对胆汁淤积型婴儿肝炎综合征胆汁酸代谢的影响 | |
| 引用本文： | 赵旸,董继萍,石来军,陈丽娜,柯炜,黎七雄. 熊去氧胆酸对胆汁淤积型婴儿肝炎综合征胆汁酸代谢的影响[J]. 医学理论与实践, 2012, 25(8): 890-891,894 |
| 作者姓名： | 赵旸 董继萍 石来军 陈丽娜 柯炜 黎七雄 |
| 作者单位： | 1. 武汉大学基础医学院,湖北省武汉市,430000;湖北医药学院附属人民医院儿科 2. 湖北医药学院附属人民医院儿科 3. 武汉大学基础医学院,湖北省武汉市,430000 |
| 摘 要： | 目的:探讨熊去氧胆酸(UDCA)对婴儿肝炎综合征(IHS)胆汁酸代谢的影响。方法:82例IHS患儿随机分为治疗组42例与对照组40例,两组病例均予保肝及综合治疗。治疗组在此基础上加用UDCA 20mg/(kg.d),分2次服用,连续应用10～15d为1个疗程。治疗2周后观察患儿血清总胆汁酸(TBA)、总胆红素(TBIL)、γ-谷氨酰基转移酶(GGT)等,判断药物疗效。结果:疗程结束后加用熊去氧胆酸治疗组TBA、TBIL、GGT下降明显,优于对照组(P<0.05);治疗组和对照组总有效率分别为95.2%和80.0%,治疗组优于对照组(P<0.05)。结论:熊去氧胆酸治疗婴儿肝炎综合征,可促进胆汁酸排泄、加速黄疸消退,安全有效。 |
| 关 键 词： | 熊去氧胆酸 婴儿肝炎综合征 胆汁酸 |
The Effects of Ursodeoxycholic Acid on Bile Acid Metabolism in Cholestatic Infantile Hepatitis Syndrome Province 430000 |
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| Affiliation: | ZHAO Yang,DONG Jiping,SHI Laijun,et al.*Basic Medical College of Wuhan University,Wuhan City,Hubei Province 430000 |
| Abstract: | Objective:Explore ursodeoxycholic acid(UDCA) on bile acid metabolism in cholestatic infantile hepatitis syndrome(IHS).Methods:82 cases of IHS were randomly divided into treatment group(n=42) with the control group of 40 cases,two groups of patients herein are hepatoprotective and comprehensive treatment.Treatment group on this basis,plus UDCA 20mg/(kg·d),divided into two doses,continuous application of 10~15days for a course.After 2 weeks of treatment,serum total bile acid(TBA),total bilirubin(TBIL),glutamyl transpepti-dase(GGT),to determine drug efficacy.Results:UDCA treatment group after treatment of TBA,TBIL,GGT in significantly decreased,than the control group(P<0.05);treatment group,control group in serum were 95.2% and 80.0%.Treatment group better than the control group(P<0.05).Conclusion:UDCA treatment of IHS promote bile acid excretion,accelerated jaundice,safe and effective. |
| Keywords: | Ursodeoxycholic acid Infant hepatitis syndrome Bile acid |
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