| 血液透析对慢性肾功能衰竭患者血清SIL2R、IL6和TNFα的影响 |
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| 引用本文： | 汪年松,唐令诠,竺艳娟,廖履坦. 血液透析对慢性肾功能衰竭患者血清SIL2R、IL6和TNFα的影响[J]. 中国危重病急救医学, 2001, 13(1): 10-11 |
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| 作者姓名： | 汪年松 唐令诠 竺艳娟 廖履坦 |
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| 作者单位： | 1. 上海市第六人民医院肾内科,
2. 上海医科大学中山医院肾内科, |
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| 基金项目： | 卫生部科研基金资助项目（No.962128） |
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| 摘 要： | 目的：探讨慢性肾功能不全（ＣＲＦ）患者细胞免疫功能状况，以及血液透析（血透）的影响。方法：应用酶联免疫吸附（ＥＬＩＳＡ）双抗体夹心法检测３０例ＣＲＦ未透析患者和６２例血透患者血透前后及对照组血清可溶性白介素－α受体（ＳＩＬ－２Ｒ）、白介素－６（ＩＬ－６）和肿瘤坏死因子－α（ＴＮＦ－α）水平。结果：与对照组相比，ＣＲＦ未透析患者和血透患者血清ＳＩＬ－２Ｒ、ＩＬ－６和ＴＮＦ－α水平无显著差异。血清ＳＩＬ－２Ｒ较透前显著增高。结论：ＣＲＦ患者均存在显著的细胞免疫功能紊乱，单次透析对细胞免疫功能无显著影响。
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| 关 键 词： | 肾功能衰竭 血液透析 白介素－2受体 肿瘤坏死因 |
| 文章编号： | 1003-0603(2001)01-0010-02 |
| 修稿时间： | 2000-04-04 |
Effects of hemodialysis on serum soluble interleukin2 receptor,interleukin6 and tumor necrosis factora in patients with chronic renal failure |
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| WANG Niansong,TANG Lingquan,ZHU Yanjuan,et al.. Effects of hemodialysis on serum soluble interleukin2 receptor,interleukin6 and tumor necrosis factora in patients with chronic renal failure[J]. Chinese critical care medicine, 2001, 13(1): 10-11 |
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| Authors: | WANG Niansong TANG Lingquan ZHU Yanjuan et al. |
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| Affiliation: | WANG Niansong,TANG Lingquan,ZHU Yanjuan,et al. 1Department of Nephrology,Shanghai Sixth People's Hospital,Shanghai 200233 |
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| Abstract: | Objective:To investigate the effects of hemodialysis (HD) on cellular immunological function in patients with chronic renal failure (CRF).Methods:Enzyme linked immunoadsorbent assay(ELISA) method was used to detect the serum soluble interleukin2 receptor(SIL2L),interleukin6(IL6)and tumor necrosis factorα(TNFα) level in 30 CRF patients without HD,62 patients with HD and 20 normal controls.Results:When compared with the control group,serum SIL2R,IL6 and TNFα levels were significantly higher in all CRF patients with or without HD and no significant difference was observed between groups.Serum SIL2R increased significantly after HD compared with that before HD,and IL6 and TNFα had no significant difference in patients before and after HD.Conclusions:The cellular immunodeficiency was observed in CRF patients and single HD therapy may have some effects on enhancing immunofunction in these patients. |
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| Keywords: | chronic renal failure hemodialysis soluble interleukin2 receptor interleukin6 tumor necrosis factorP |
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