| 胃复安、西沙必利和红霉素对暴发性肝功能衰竭大鼠胃肠运动的影响 |
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| 引用本文： | 彭佩芬 仉若愚 等. 胃复安、西沙必利和红霉素对暴发性肝功能衰竭大鼠胃肠运动的影响[J]. 郧阳医学院学报, 1997, 16(4): 181-183 |
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| 作者姓名： | 彭佩芬 仉若愚 等 |
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| 作者单位： | 武汉市卫生学校，同济医科大学，武汉冶金科技大学医学院 |
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| 摘 要： | 目的：观察胃复安、西沙必利和红霉素对暴发性肝功能衰竭（ＦＨＦ）大鼠胃肠运动的影响。方法：用硫代乙酰胺复制大鼠ＦＨＦ模型，定点记录大鼠胃肠运动。结果：（１）肌肉注射胃复安、西沙必利或红霉素分别使ＦＨＦ大鼠的胃、十二指肠和降结肠的运动增强；（２）上述效应可被皮下注射阿托品或切断膈下迷走神经所完全阻断；（３）胃复安、西沙必利和红霉素对ＦＨＦ大鼠的离体十二指肠运动均有明显的直接抑制作用。结论：胃复安、西沙必利和红霉素可能是通过兴奋胃肠道副交感神经而增强ＦＨＦ大鼠的胃肠运动的。
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| 关 键 词： | 胃肠活动 肝疾病 胃复安 西沙必利 红霉素 大鼠 |
Effect of Metoclopramide,Cisapride and Erythromycin on Gastrointestinal Motility in Rats of Fulminant Hepatic Failue by Thioacetamide |
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| Abstract: | Objective: To observe the effect of metoclopramide,cisapride and erythromycin on gastrointestinal motility in rats of fulminant hepatic failuye (FHF).Methods:The model of FHF was reconstructed by thioacetamide,and gastrointestinal motility in rats was writen down.Results:(1) The motility of stomach,duodenum and descending colon was enhanced when metoclopramide,cosapride or erythromycin was injected into the muscle of the FHF rats.(2) These effects Were completly blocked by subcuta-neous injection of atropine or by bilateteral vagotomy. (3) The motility of isolated duodenum of FHF rats wsa significantly inhibited by metoclopramide,cisapride or erythromycin respectly.Conclusion:The enhanced activity of metoclopramide,cisapride and erythromycin is mediated by parasympathetic nerve to cause some increase in gastrointestinal motility. |
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| Keywords: | liver diseases metoclopramide cisapride erythromycin rat gastrointestinal motility |
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