| 卡氏肺孢子虫小鼠动物模型的研究 |
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| 引用本文： | 郭鄂平,侯襄河,等.卡氏肺孢子虫小鼠动物模型的研究[J].郧阳医学院学报,1997,16(2):70-72. |
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| 作者姓名： | 郭鄂平 侯襄河 |
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| 作者单位： | 郧阳医学院寄生虫学教研室 |
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| 摘 要： | 目的：建立卡氏肺孢子虫小鼠动物模型。方法：昆明小鼠１６只，每次皮下注射醋酸可的松１～２ｍｇ，每周２次，诱发小鼠卡氏肺孢子虫肺炎模型。结果：用药５周肺印片即可检出卡氏肺孢子虫包囊，８周后大部分小鼠可检出，总检出率为６８．７５％。姬氏染色肺印片可查见成熟包囊、未成熟包囊，形态典型，是显示肺印片中包囊的可靠方法。ＧＭＳ染色是显示肺组织石蜡切片中包囊的可靠方法。结论：提示小鼠可能是建立卡氏肺孢子虫动物模型的理想动物
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| 关 键 词： | 免疫抑制 动物模型 卡氏肺孢子虫 卡氏肺孢子虫肺炎 |
Studies on Mice Animal Model of Pneumocystis Carinii |
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| Abstract: | Objective:To develop the mice animal model of Pneumocystis carinii.Methods:Sixteen Kunming Mice underwent subcutaneous injection of cortisone acetate twice per week,1～2 mg each time so that mice model of pneumocystis carinii pneumonia(PCP) was induced.Results:After 5-week administration of the drug,the cysts of pneumocystis carinii could be found in the pulmonary impression.8 weeks later,such cysts could be detected in most mice,the total detectable rate being 68.75%.From the pulmonary impression by Giemsa's stain is a reliable method with which to show the cysts in the pulmonary impression.Gomori-Grocott's methenamine silver(GMS) stain is a reliable method with which to show the cysts in the paraffin section of lung tissue.Conclusion:Mice might be the ideal animal for the production of animal model of pneumocystis carinii. |
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| Keywords: | immunosuppression animal model pneumocystis carinii pneumocystis carinii pneumonia |
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