蠲痛饮对子宫内膜异位症大鼠ICAM-1的影响

目的:探讨蠲痛饮对子宫内膜异位症大鼠血清、腹腔液sICAM-1及异位病灶内膜ICAM-1表达的影响。方法:将SPF级雌性SD大鼠随机分成蠲痛饮低、中、高剂量组、孕三烯酮组、模型组及空白对照组,以观察蠲痛饮对子宫内膜异位症大鼠血清、腹腔液sICAM-1及异位病灶内膜ICAM-1表达的影响。结果:与模型组比较,蠲痛饮低、中、高剂量组和孕三烯酮组大鼠腹腔液sICAM-1水平均明显降低,并且蠲痛饮低、中、高剂量组大鼠腹腔液sICAM-1逐渐降低,呈量效关系;与模型组比较,蠲痛饮中、高剂量组和孕三烯酮组大鼠异位病灶内膜ICAM-1表达均明显下降,并且蠲痛饮中、高剂量组大鼠异位病灶内膜ICAM-1表达逐渐减弱,呈量效关系;与模型组比较,蠲痛饮低、中、高剂量组和孕三烯酮组大鼠血清sICAM-1水平无明显差异。结论:蠲痛饮能降低腹腔液sICAM-1水平及异位病灶内膜ICAM-1的表达,这可能是蠲痛饮治疗子宫内膜异位症的作用机制之一。

The Impact of Juan Tong Decoction Over ICAM-1 of Endometriosis rat

Objective：To explore the impact of Juan tong Decoction over the serum and peritoneal fluid sICAM-1 of Endometriosis rat and the ICAM-1 expression of Ectopic endometrial lesions. Methods：The SPF level of female SD rats were randomly divided into high,medium and low dose group,Gestrinone group,model group and blank control group,in order to observe the impact of Juan tong decoction over endometriosis rat serum and peritoneal fluid,digital expression of allogeneic endometrial lesions. Results：The peritoneal fluid sICAM-1 level of high,medium and low-dose group and Gestrinone group were significantly lower than the model group,and the peritoneal fluid sICAM-1 level reducing between high,medium and low dose group was dose-effect relationship; high,medium-dose group and Gestrinone group of rat ectopic endometrial lesions express ICAM-1 were significantly lower than model group,and high,medium dose group of rat ectopic endometrial lesions ICAM-1 expression was reduced dose-effect relationship. The serum sICAM-1 level of high,medium and low-dose group and Gestrinone group were not significantly different between the model group. Conclusion：Juan tong Decoction could reduce the peritoneal fluid sICAM-1 level as well as ectopic endometrial lesions ICAM-1 expression,this may be one of the mechanisms in the treatment of endometriosis using Juan tong Decoction.