补肾温阳化瘀方对子宫内膜异位症血管生成的影响

目的:探讨VEGF、MVD在子宫内膜异位症的表达及意义,探索补肾温阳化瘀方治疗子宫内膜异位症的疗效及机理。方法:采用免疫组织化学SP法测定VEGF、MVD在内异症在位、异位内膜中的表达,采用补肾温阳化瘀方治疗内异症患者50例,观察治疗前后血清中VEGF、CA125的变化。结果:内异症中VEGF、MVD的表达较正常组内膜明显增高(均为P<0.01),中药治疗本病总有效率为82.00%,并且能降低内异症患者血清中VEGF、CA125的含量。结论:VEGF、MVD在内异症中过度表达,提示血管生成是内异症发生发展的重要环节,补肾温阳化瘀方可降低内异症患者血清中VEGF、CA125的含量,阻断内异症的血管生成,促使病灶消散、吸收,并可调节患者紊乱的免疫功能,为治疗内异症的有效方药。

The Effect of Tonifying Kidney Warming yang Removing Blood Stasis Recipe on the Angiogenesis of Endometriosis

Objective：To detect the expression and meaning of VEGF、MVD in endometriosis and research the mechanism of action of Tonifying kidney warming yang removing blood stasis recipe treated on endometriosis. Methods：Immuno-histochemical staining was used to detect VEGF、MVD expression in eutopic and ectopic endometrium. Apply the recipe to treat the patients with endometriosis and detect the contents of VEGF、CA125 in serum. Results：The expressions of VEGF、MVD in endometriosis were higher than in normal group（ all P 0. 01） ,The total effective rate of traditional Chinese medicine group was 82. 00% ,and the recipe could decrease the content of serum VEGF、CA125 in endometriosis. Conclusion：The overexpressions of VEGF and MVD in endometriosis had a significant relation with angiogenesis,may play an important role in pathogenesis of endometriosis. The recipe could decrease the value of serum VEGF、CA125 of patients with endometriosis,and intercept the angiogenesis in endometriosis,precipitate the ectopic focus disappear、absorption,it is an active recipe to cure endometriosis.