| 有机凝胶在药物传递系统中的应用 |
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| 引用本文： | 王可可,贾 强,李三鸣.有机凝胶在药物传递系统中的应用[J].沈阳药科大学学报,2010,27(9):759-766. |
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| 作者姓名： | 王可可 贾 强 李三鸣 |
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| 作者单位： | 1. 沈阳药科大学 药学院，辽宁 沈阳 110016；2. 澳美制药有限公司，香港 999077 |
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| 摘 要： | 目的介绍有机凝胶的分类及其在药学中的应用情况。方法参阅国内外代表性文献资料,以其中的53篇为依据对其进行分析、归纳和整理。结果阐明了不同种类有机凝胶的分子特点、结构类型及凝胶形成机理,并对其在经皮给药、皮下植入、口服和黏膜给药等方面的应用加以综述。结论有机凝胶在药学领域具有广阔的应用及发展前景。
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| 关 键 词： | 有机凝胶 有机凝胶因子 经皮给药 皮下贮库 口服给药 粘膜给药 |
| 收稿时间： | 2009-11-12 |
| 修稿时间： | 2010-1-12 |
Use of organogels in drug delivery |
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| WANG Ke-ke,JIA Qiang,LI San-ming.Use of organogels in drug delivery[J].Journal of Shenyang Pharmaceutical University,2010,27(9):759-766. |
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| Authors: | WANG Ke-ke JIA Qiang LI San-ming |
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| Institution: | 1. School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China；2. Bright Future Pharmaceutical Co. Ltd., Hongkang 999077, China |
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| Abstract: | Objective To summarize the species of organogels and their applications in drug delivery. Methods At least 53 representative papers recently published were consulted, analyzed and summarized. Results The molecular properties, structure types and formation mechanisms of different organogels were illustrated; their applications in transdermal, parenteral depot, oral and trans-mucosal formulations were reviewed. Conclusions The organogel systems have become widely known as a very attractive platform for drug delivery. |
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| Keywords: | organogel organogelator transdermal formulation parenteral depot formulation oral formulation trans-mucosal formulation |
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