| 遵义地区人群维生素D受体基因外显子2多态性 |
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| 引用本文： | 张志敏,肖代敏,李学英.遵义地区人群维生素D受体基因外显子2多态性[J].现代医药卫生,2013(22):3386-3387. |
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| 作者姓名： | 张志敏 肖代敏 李学英 |
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| 作者单位： | [1]遵义医学院细胞生物学与遗传学教研室,贵州遵义563099 [2]遵义医学院附属医院检验科,贵州遵义563099 |
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| 基金项目： | 贵州省科技厅联合基金（黔科合J字LKZ[2012]39号）. |
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| 摘 要： | 目的探讨遵义地区人群维生素D受体（VDR）基因第2外显子（起始密码子，e2）的单核苷酸多态性分布情况。方法收集110例遵义地区汉族人群静脉血标本，采用聚合酶链反应．限制性片段长度多态性法测定VDR基因e2序列多态性．分析该人群中基因型频率和基因频率分布规律。结果FokI的等位基因频率为F0．741、f0．259。结论VDR基因e2序列在遵义地区汉族中的分布具有多态性。
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| 关 键 词： | 受体 骨化三醇 基因 多态性 单核苷酸 基因型 汉族 遵义 |
Polymorphism of exon 2 of vitamin D receptor gene in population in Zunyi region |
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| Zhang Zhimin,Xiao Daimin,Li Xueying.Polymorphism of exon 2 of vitamin D receptor gene in population in Zunyi region[J].Modern Medicine Health,2013(22):3386-3387. |
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| Authors: | Zhang Zhimin Xiao Daimin Li Xueying |
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| Institution: | 1. Department of Cell Biology and Genetics ,Zunyi Medical College ,Zunyi, Guizhou 563099, China;2. Department of Clinicol Laboratory,Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563099, China) |
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| Abstract: | Objective To investigate the distribution of single nucleotide polymorphism in exon 2（initiation codon,e2） of vitamin D receptor （VDR） gene in Zunyi region. Methods 110 samples of venous blood from Han population in Zunyi region were collected. Polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP） was adopted to determine the polymorphism of VDR gene to analyze the distribution law of genotype frequency and gene frequency among the population. Resuits The Allele frequency of Fok I was F 0.741 and f 0.259. Conclusion The distribution of e2 sequence of VDR gene has polymorphisms among Han nationality in Zunyi region. |
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| Keywords: | Receptors calcitriol Gene Polymorphism Single nucleotide Genotype Han nationality Zunyi |
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