磁处理对12种抗菌药物体外抑菌效果的影响

目的探索利用外界环境条件增强抗菌药物药效的方法，为降低抗茵药物使用量、减少细菌耐药性的发生提供依据。方法通过设计自制药物处理箱，考察3种不同强度静磁场对12种抗茵药物体外抑茵效果的影响。结果经过3种强度静磁场处理后。对应于6000、4000和1500Gs强度的氨基糖苷类抗生素抑茵圈直径变化率分别为链霉素37．03％、24．59％、19．38％，庆大霉素48．63％、40．73％、35．06％；林克酰胺类抗生素林可霉素25．00％、25．00％、12．50％，克林霉素37．86％、21．43％、28．57％；B．内酰胺类抗生素氨苄西林10．87％、15．82％、13．00％，阿莫西林1．98％、1．14％、-4．33％；大环内酯类抗生素阿奇霉素-8．70％、-1．63％、1．09％，泰乐菌素2．25％、1．12％、1．12％；氟喹诺酮类药物恩诺沙星2．48％、5．45％、0．99％，左氧氟沙星-5．33％、0．94％、0．63％；头孢类抗生素头孢拉定-0．96％、-1．53％、-1．21％．头孢噻呋钠-0．69％、-1．23％、-1．23％。表明磁场可增强氨基糖苷类抗生素（链霉素和庆大霉素）、林克酰胺类抗生素（林可霉素和克林霉素）的体外抑茵效果；B．内酰胺类（氨苄西林和阿莫西林）、大环内酯类（阿奇霉素和泰乐茵素）以及氟喹诺酮类药物均未受影响；而头孢类抗生素（头孢拉定和头孢噻呋钠）则受到抑制。结论通过适当改变外界环境可以对抗菌药物的药效发挥产生不同影响。

Influence of magnetic treatment on the bacteriostasis in vitro of 12 kinds of antibacterials

Objective To find a way to enhance the pharmaeodynamie action of antibacterials by using external environ- mental conditions ,to provide the basis for decreasing the drug dosage and the appearance of bacterial drug resistance. Methods Home-made medication box was designed to inspect the influence of three different levels of magnetostatie field on the in vitro bacteriostasis of 12 kinds of antibacterials. Results After the magnetostatic field treament, variation rate of diameter of inhibition zone corresponding to 6 000 Gs,4 000 Gs and 1 500 Gs for streptomycin was 37.03%, 24.59% and 19.38% respectively ;for gen- tamycin was 48.63% ,40.73% and 35.06% respectively ;for lincomycin of lincosamides was 25.00% ,25.00% and 12.50% respec- tively;for elindamyein was 37.86% ,21.43% and 28.57% respectively;for ampieillin of beta-lactam antibiotics was 10.87%, 15.82% and 13.00% respectively ;for amoxicillin was 1.98%, 1.14% and -4.33% respectively;for azithromyein of maerolides an- tibiotics was -8.70%, -1.63% and 1.09% respectively;for tylosin was 2.25%, 1.12% and 1.12% respectively ;for enrofloxaein of fluoroquinolones was 2.48%, 5.45% and 0.99% respectively ;for levofloxaein was -5.33%, 0.94% and 0.63% respectively ;for ee- fradine of eephalosporin antibiotics was -0.96%,-1.53% and -1.21% respectively; for eeftiofur Sodium was -0.69%,-1.23% and -1.23% respectively. The above indicated that magnetic field could strengthen the antibacterial effect in vitro of aminoglyeoside antibiotics （streptomycin and gentamyein） and lineomyein antibiotics （ lineomyein and elindamyein） ; beta-laetam antibiotics （ampi- eillin and amoxieillin）,lineosamides（azithromyein and tylosin） and fluoroquinolones were all not affected by magnetic field; con- versely, cephalosporin antibiotics （cefradine and eeftiofur sodium） was restrained. Conclusion Appriopriate change ofexternal environment has different influence on the efficacy of antibacterial agents.