抗焦虑抑郁药物对难治性胃食管反流病辅助治疗作用的临床研究

目的 探讨抗焦虑抑郁药物联合质子泵抑制剂对难治性胃食管反流病（RGERD）的治疗作用.方法 将92例RGERD患者分为治疗组和对照组,每组包含26例伴焦虑抑郁者和20例不伴焦虑抑郁者.治疗组给予氟哌噻吨美利曲辛和雷贝拉唑钠肠溶胶囊,对照组给予雷贝拉唑钠肠溶胶囊,疗程均为8周.疗程结束后利用GerdQ量表评价疗效并观察不良反应.治疗组与对照组间以及各组伴有焦虑抑郁患者与不伴有焦虑抑郁患者间进行方差分析.结果 治疗组有效率高于对照组,P＜0.05.治疗组中伴焦虑抑郁者疗效优于不伴焦虑抑郁者,P＜0.05.对照组中伴焦虑抑郁者疗效与不伴焦虑抑郁者疗效无统计学差异,P〉0.05.治疗组中伴焦虑抑郁者疗效优于对照组中伴焦虑抑郁者,P＜0.05.治疗组中不伴焦虑抑郁者疗效与对照组中不伴焦虑抑郁者疗效无统计学差异,P〉0.05.各组均未发生显著不良反应.结论 抗焦虑抑郁药物联合质子泵抑制剂治疗RGERD疗效优于单用质子泵抑制剂.

Study of the treatment effects of anxiolytics and antidepressants on refractory gastroesophageal reflux disease

Objective To investigate the efficacy of anxiolytics and antidepressants combined proton pump inhibitors（PPI） in the treatment of refractory gastroesophageal reflux disease（RGERD）. Methods A total of 92 RGERD patients were evenly divided into treatment group and control group, and each group include 26 patients with anxiety and depression and 20 patients without anxiety and depression. Both flupethixol melitracen and rabeprazole sodium were administrated in treatment group. Only rabeprazole sodium was given in control group. The treatment course of two groups was 8 weeks. Therapeutic efficiency was evaluated according the gastroesophageal reflux disease questionnaire after the treatment. Adverse effects were also ob- served. Variance analysis was performed the comparison between two groups and the comparison among four parts of the pa- tients. Results The curative effect of treatment group was better than control group, P〈0.05. The curative effect of patients with anxiety and depression was better than patients without anxiety and depression in treatment group, P〈0.05. There was no significant difference in efficacy between two parts of control group, P〉0.05. The curative effect of patients with anxiety and depression in treatment group was better than patients with anxiety and depression in control group, P〈0.05. There was no significant difference in efficacy between patients without anxiety and depression in treatment group and patients without anxiety and depression in control group, P〉0.05. There was no significant adverse reaction in either group. Conclusion For RGERD patients, anxiolytics and antidepressants can be used and the effect is superior to using PPI alone.