恶性肿瘤患者血液中LPO,SOD,GSH—PX临床价值的初步分析

本文对１０９例恶性肿瘤及５０例正常对照者血浆脂质过氧化物（ＬＰＯ）、全血超氧化物歧化酶（ＳＯＤ）及谷胱甘肽过氧化物酶（ＧＳＨ—ＰＸ）进行测定，结果显示：结肠癌的ＬＰＯ值最高；胃癌的ＳＯＤ值最高；骨癌的ＧＳＨ—ＰＸ值最高。各肿瘤组之间，肿瘤组与正常对照组之间两两比较，ｑ检验，多数组间的Ｐ＜０．０１或ＰＭ０．０５，ＳＯＤ与ＬＰＯ呈负相关，ｒ＝０．１７，Ｐ＜０．０５。经判别分析，在Ｆ＝３水平上选入ＬＰＯ、ＳＯＤ、ＧＳＨ—ＰＸ三因素与判别癌与非癌有关，符合率达８０．５％，特异性９０％，灵敏性７６．１％，可供探讨肿瘤与自由基的关系及临床诊断作参考。

Clinical Significance of LPO, SOD and GSH-PX Content in Blood of Patient with Malignant Tumor

This paper deals with the role of content of Lipoperoxides(LPO), Superoxide dismustase(SOD) and Glutathion peroxidase(GSH-PX)in blood of 109 cases of malignant tumor and 50 cases of normal subjects as control.The results indicated that the level of LPO was the highest in patient with colon cancer, SOD in gastric carcinoma and GHS-PX in bone malignancy. Comparisons made between every two tumor groups snd between one tumor group with controls were found to be marked being P<0.01 or P<0.05 for most pairs whereas a negative correlation between SOD and LPO(r=0.17 was observed, P<0.05). In me discriminant analysis,it was found that LPO, SOD and GSH-PX at the level of F=3 could be taken as indices and that they showed clear cut demarcation of tumor from nontumor with an accuracy rate of 80. 5%, and a specificity rate of 90% as well as a sensitivity rate of 76. 1%. This result suggest that it could be used todetermine the association between free radicals andtumor growth and be useful in diagnosis.