Improvement of In Vitro and In Vivo Antileishmanial Activities of 2′,6′-Dihydroxy-4′-Methoxychalcone by Entrapment in Poly(d,l-Lactide) Nanoparticles |
| |
| Authors: | Eduardo Caio Torres-Santos, Jos M. Rodrigues, Jr., Davyson L. Moreira, Maria Auxiliadora C. Kaplan, Bartira Rossi-Bergmann |
| |
| Affiliation: | Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. |
| |
| Abstract: | The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions. |
| |
| Keywords: | |
|
|
