阿立哌唑对精神分裂症患者的疗效及对生活质量的影响

目的:比较阿立哌唑片与氟哌啶醇片治疗精神分裂症的临床疗效和不良反应,同时探讨两药对精神分裂症患者生活质量的影响.方法:随机将70例首发精神分裂症的患者分成阿立哌唑组和氟哌啶醇组,每组35例.分别于治疗前及治疗后第1、2、4和8周末评定PANSS、TESS量表,行实验室检查及心电图检查.疗效按PANSS总分减分率来评定.于入组时及第12周末用世界卫生组织编制的生活质量量表(WHOQOL-100)评定两组患者生活质量.结论:两组疗效相仿,但阿立哌唑组对阴性症状改善明显优于氟哌啶醇组,且服用方便安全,不良反应显著较少;两组比较阿立哌唑组对生活质量改善显著优于氟哌啶醇组,且患者服药依从性好.

Clinical efficacy and the life quality of aripiprazole in treatment of schizophrenia

OBJECTIVE 1.To compare the efficacy and safety of aripiprazole and haloperidol in treatment of schizophrenia.2.To compare the life quality of schizophrenia patients with the two drugs.METHODS 70 patients with the diagnosis of first-episode schizophrenia were randomly assigned to aripiprazole or haloperidol treatment.Every patient was scored at the beginning of the study and the last two,four,eight weeks.The Positive and Negative Syndrome Scale(PANSS)was used to assess efficacy.The Treatment Emergent Syndrom...