脑囊虫病患儿细胞免疫功能研究

目的检测28例脑囊虫病患儿外周血白细胞介素2（IL-2）、可溶性白细胞介素2受体（sIL-2R）、白细胞介素6和8（IL-6和IL-8）和T淋巴细胞亚群，以探讨其免疫学发病机制。方法IL-2、sIL-2R、IL-6、IL-8和T淋巴细胞亚群检测，分别采用ELISA、双抗体夹心ELISA和APAAP法进行。结果脑囊虫病患儿外周血CD3＋、CD4＋细胞百分率、CIM＋／CD8＋比值和IL-2水平均显著低于对照组（P〈0．01），sIL-2R、IL-6、IL-8水平均显著高于对照组（P〈0．01）。结论脑囊虫病患儿细胞免疫功能低下且紊乱，患儿机体的免疫功能障碍在该病的发生中起一定作用。

Study on cellular immunity of children with brain cysticercosis

Objective To examine the levels of interleukin-2(IL-2),soluble IL-2 receptor(sIL-2R),interleukin-6(IL-6),interleukin-8(IL-8),and T-lymphocyte subsets in peripheral blood of 28 children with brain cysticercosisand in order to discuss its immunological pathogenesis.Methods ELISA,double antibody sandwich ELISA,and APAAP were respectively used to detect the levels of IL-2,sIL-2R,IL-6,IL-8,and T-lymphocyte subsets.Results The percentages of CD3+ and CD4+ cells and the ratio of CD4+ to CD8+ cells as well as IL-2 level in peripheral blood of children with brain cysticercosisand were significantly lower than those of the control group(P<0.01).The levels of sIL-2R,IL-6,and IL-8 were significantly higher than those of the control group(P<0.01).Conclusion The cellular immunity function is low and disordered in children with brain cysticercosis,and their immune dysfunction plays a certain role in the onset of this disease.