| 联合检测肺癌血清中TSGF、NSE和CYFRA21-1的临床价值 |
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| 引用本文： | 黄文成,陈闯,潘泓,朱波,黄玲莎,陈铃,李晖,赵惠柳,劳明,王英,黄昭东.联合检测肺癌血清中TSGF、NSE和CYFRA21-1的临床价值[J].中国现代医学杂志,2008,18(3):305-308,312. |
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| 作者姓名： | 黄文成 陈闯 潘泓 朱波 黄玲莎 陈铃 李晖 赵惠柳 劳明 王英 黄昭东 |
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| 作者单位： | 广西医科大学附属肿瘤医院,广西,南宁,530021 |
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| 摘 要： | 目的探讨肺癌患者血清中恶性肿瘤相关物质TSGF、NSE和CYFRA21—1的水平及其临床意义。方法用电化学发光免疫法（ECLIA）检测210例肺癌患者、44例肺良性疾病患者及112例健康对照血清NSE和CYFRA21—1水平，同时用光电比色法检测其血清TSGF水平。结果与肺良性疾病组及健康对照组相比，肺癌患者血清中3项标志物的水平明显升高（P〈0．05）。3项标志物的水平和敏感性与病理类型、非小细胞肺癌（NSCLC）临床分期及淋巴结转移有关（P〈0．05）。TSGF、NSE及CYFRA21—1判别肺癌血清的敏感性分别为60．O％、38．1％和59．5％，特异性分别为92．9％、93．6％和96．8％，3项标志物联合检测判别肺癌血清的敏感性和特异性分别为87．6％和84．0％。治疗前及治疗后无效组患者血清3项标志物的水平均明显高于治疗后有效组（P〈0．05）。结论血清TSGF、NSE及CYFRA21—1联合检测在肺癌诊断、病情监测及疗效判断方面具有较重要的临床价值，三者联合检测可明显提高肺癌诊断的敏感性。
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| 关 键 词： | 肺癌 TSGF NSE CYFRA21-1 肿瘤标志物 联合检测 非小细胞肺癌 血清 TSGF 临床价值 serum detection combined value Clinical 疗效判断 病情监测 癌诊断 有效组 治疗 敏感性和特异性 判别 淋巴结转移 临床分期 NSCLC |
| 文章编号： | 1005-8982（2008）03-0305-04 |
| 收稿时间： | 2007-09-01 |
| 修稿时间： | 2007年9月1日 |
Clinical value of combined detection of serumTSGF,NSE and CYFRA21-1 in lung cancer |
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| HUANG Wen-cheng,CHEN Chuang,PAN Hong,ZHU Bo,HUANG Ling-sha,CHEN Ling,LI Hui,ZHAO Hui-liu,LAO Ming,WANG Ying,HUANG Shao-dong.Clinical value of combined detection of serumTSGF,NSE and CYFRA21-1 in lung cancer[J].China Journal of Modern Medicine,2008,18(3):305-308,312. |
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| Authors: | HUANG Wen-cheng CHEN Chuang PAN Hong ZHU Bo HUANG Ling-sha CHEN Ling LI Hui ZHAO Hui-liu LAO Ming WANG Ying HUANG Shao-dong |
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| Institution: | HUANG Wen-cheng,CHEN Chuang,PAN Hong,ZHU Bo,HUANG Ling-sha,CHEN Ling,LI Hui,ZHAO Hui-liu,LAO Ming,WANG Ying,HUANG Shao-dong (The Affiliated Cancer Hospital of Guangxi Medical University,Nanning,Guangxi 530021,P.R.China) |
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| Abstract: | Objective To detect the clinical significance of serum tumor supplies group of factors (TSGF ),NSE and CYFRA21-1 in patients with lung cancer. Methods The serum levels of NSE,CYFRA21-1 and TSGF in 210 patients with lung cancer,44 patients with benign lung disease and 112 healthy controls were measured by Elctrochemiluminescence immuno-assay (ECLIA) and spectrophotometry. Results The serum levels of TSGF,NSE and CYFRA21-1 in patients with lung cancer were significantly higher than those in benign lung diseas... |
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| Keywords: | lung cancer TSGF NSE CYFRA21-1 tumor marker |
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