脑梗死和脑出血患者NO、ET和血液流变学变化的对照研究

目的 探讨脑梗死与脑出血患者NO、ET和血液流变学各项指标的改变，并探讨其临床意义。方法全组包括脑梗死66例、脑出血27例，健康对照组103例，分别以硝基还原酶法和放射免疫法测定血清NO含量和血浆ET含量，并检测患者血液流变学各项指标，脑梗死组及脑出血组分别与对照组比较，以及脑梗死组与脑出血组比较。结果与对照组相比，脑梗死与脑出血血流动力学与血液流变学各有多项指标出现显著变化。两组间比较，NO、ET的改变无显著性差异，低切全血粘度、高切全血粘度、血浆粘度、红细胞压积、红细胞聚集指数、刚性指数、电泳指数有显著性差异。结论脑梗死和脑出血患者血流动力学和血液流变学较正常对照组有显著差异，两组比较也有显著不同。

The Comparison of NO,ET and Hemokinetics between the Cerebral Infarction and the Intracerebral Hemorrhage

Objective To examine the diffcrence in plasma NO,ET levels and hemokinetics between patients of the cerebral infarction and the intracerebral hemorrhage. Methods Sixty-six cerebral infarction patients,27 intracerebral hemorrhage patients,and 103 healthy controls participated in this study. Plasma NO and ET were measured by nitratereductase and radioimmunoassay methods, respecdvely. And hemokinetics was determined in each subjects. The results were compared among the different groups. Results The results showed a significant difference between the patient group and the healthy control group. There was also a statistically signifiant difference between cerebral infarction and intracerebral hemorrhage patients on the blood viscosity at low and high shear rate, plasma viscosity, hematocrit, erythrocyte aggregation, rigidity, deformation and electrovhoresis. Conclusion This study suggested that there was a significant differences on NO, ET levels and hemokinetics between healthy controls and stroke patients,and as well as between patients with cerebral infarction and intracerebral hemorrhage.