日本血吸虫病与肠线虫病联合化疗的效果

血吸虫病人合并感染肠线虫者(A组)采取;吡喹酮40mg/kg加阿苯达唑200mg和复方甲苯咪唑400mg(尚含左旋咪唑100mg)分2d顿服,1个半月后血吸虫阴转率88.0％,蛔虫、鞭虫和钩虫阴转率分别为77.4％、23.6％及100.0％。对不合并血吸虫病的肠线虫病患者采取两种联合化疗方案:B组—阿苯达唑200mg和复方甲苯咪唑200mg(尚含左旋咪唑50mg)顿服,蛔虫、鞭虫和钩虫的阴转率分别为66.7％、18.8％和62.5％,较A组结果稍低;C组—阿苯达唑100mg和噻嘧啶900mg顿服的驱虫效果差,蛔虫和鞭虫的阴转率分别为50.0％及11.1％。3种驱虫方案对血吸虫和蛔虫的减卵率可达97.0％～99.9％;对钩虫的减卵率达68.9％～100％;对鞭虫的效果差。相应增加药物的剂量及改进服法,当可提高疗效。

COMBINED CHEMOTHERAPY OF SCHISTOSOMIASIS AND INTESTINAL NEMATODIASIS

Patients infected with Schistosoma japonicum and/or intestinal nemtodes were conducted with combined chemotherapy in three groups:Group A: 67 cases were treated with a single dose (40mg/kg) of praziquantel on first day and with a single dose of albendazole (200mg) and mebendazole Co. (mebendazole 400mg and levamisole 100mg) in next day. 11/2 month after treatment the cure rate of schis-tosomiasis was 88. 0%. and of ascariasis, trichuriasis and hookworm infection were 77. 4%, 23. 6% and 100% respectively. Group B: 54 cases infected with intestinal nematodes only were treated with a single dose (200mg) of albendazole and mebendazloe Co. (mebendazole 200mg and levamisole 50mg). The cure rate were; ascaris 66. 7%. trichris 18. 8% and hookworm infection 62. 5%. Group C: 21 cases infected with ascaris and trichuris only were treated with a single dose of albendazole (l00mg) and pyranter pamoate (900mg). The cure rate of ascaris was 51. 5% and trichuris was 11. 1%.Through these three chemotherapy regimes, it showed that the egg reduction rates were higher in schistosome and ascaris infections (97. 0%-99. 9%). and moderate in hookworm infection (68. 9%-100%). The result of treatment for whipworm infection was poor, the cure rate was low and there was no reduction of the eggs. The results showed that with increase of drug dosage the result of treatment would be better.