High field MRI correlates of myelincontent and axonal density in multiple sclerosis |
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| Authors: | J. P. Mottershead MRCP K. Schmierer MD M. Clemence PhD J. S. Thornton PhD F. Scaravilli FRCPath G. J. Barker PhD P. S. Tofts PhD J. Newcombe PhD M. L. Cuzner PhD R. J. Ordidge PhD W. I. McDonald FRCP Prof. D. H. Miller FRCP |
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| Affiliation: | (1) Dept. of Neuroinflammation, MS NMR Research Unit, Institute of Neurology, UCL, London, WC1N 3BG, UK;(2) Dept. of Molecular Pathogenesis, Divison of Neuropathology, Institute of Neurology, UCL, London, UK;(3) Dept. of Medical Physics, University College London, London, UK |
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| Abstract: | Abstract. Different MRI techniques are used to investigate multiplesclerosis (MS) in vivo. Thepathological specificity of these techniques is poorlyunderstood, in particular their relationship to demyelinationand axonal loss.The aim of this study was to evaluate the pathologicalsubstrate of high field MRI in post-mortem (PM) spinal cord (SC)of patients with MS. MRI was performed in PMSCs of four MSpatients and a healthy subject on a 7 Tesla machine.Quantitative MRI maps (PD; T2; T1; magnetization transferratio, MTR; diffusion weighted imaging) were obtained. Afterscanning, the myelin content and the axonal density of thespecimens were evaluated neuropathologically using quantitativetechniques. Myelin content and axonal density correlatedstrongly with MTR, T1, PD, and diffusion anisotropy, but onlymoderately with T2 and weakly with the apparent diffusioncoefficient.Quantitative MR measures provide a promising tool toevaluate components of MS pathology that are clinicallymeaningful. Further studies are warranted to investigate thepotential of new quantitative MR measures to enable adistinction between axonal loss and demyelination and betweendemyelinated and remyelinated lesions. |
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| Keywords: | high field MRI pathology neuropathology multiple sclerosis spinal cord |
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