咪达唑仑对顺铂诱发猫呕吐的预防作用

目的 探讨咪达唑仑预防顺铂诱发猫恶心、呕吐的效果.方法 健康杂种家猫18只,随机分为3组：单纯模型组（顺铂组,C组）、格拉斯琼组（G组）和咪达唑仑组（M组）,每组6只,分别静注生理盐水3ml、格拉斯琼0.15mg/kg和咪达唑仑0.50mg/kg,20min后顺铂3mg/kg腹腔注射.观察动物镇静程度和10h内恶心、呕吐情况.结果 顺铂能诱发猫产生严重的恶心、呕吐反应;G组和M组猫干呕潜伏期延长,恶心、呕吐次数减少（P＜0.01）.结论 猫静脉注射咪达唑仑0.5 mg/kg能预防顺铂诱发的恶心、呕吐.

Antiemetic Effect of Midazolam on Cisplatin Induced Nausea and Vomiting in Cats

Objective To evaluate the antiemetic effect of midazolam on cisplatin induced nausea and vomiting in cats. Methods Eighteen heahhy eats were divided into 3 groups （ n = 6 ） ： the control group （ eisplalin group, Grnup C ） , granisetron group （ Group G ） and midazolam group （ Group M ）. The eats were given cisplatin 3 mg/kg, ip 20 minutes after the administration of normal saline 3ml, granisetron 0. 15mg/kgand midazolam 0.50 mg/kg,respectively. The sedative effects and emesis reaetions of cats in subsequently 10h were observed. Results The cats in cisplatin group experienced serious nausea and vomiting reaction. Compared with the control group,the retching latency was longer,frequency of nausea and vomiting was tewer in Group G and Group M （ P 〈 0.05 ）. Conclusion Midaznlam 0.50mg/kg IV can prevent the emesis and vomiting caused by cisplatin ip in cats.