| 卡托普利对腹主动脉缩窄大鼠血浆心房利钠肽水平的影响 |
| |
| 引用本文： | 董晓蕾,赵智明,焦东东,沈思钰,赵凌杰. 卡托普利对腹主动脉缩窄大鼠血浆心房利钠肽水平的影响[J]. 现代中西医结合杂志, 2010, 19(16): 1969-1970,2035 |
| |
| 作者姓名： | 董晓蕾 赵智明 焦东东 沈思钰 赵凌杰 |
| |
| 作者单位： | 南京军区南京总医院,江苏,南京,210002 |
| |
| 基金项目： | 江苏省"六大人才高峰"资助基金 |
| |
| 摘 要： | 目的观察卡托普利对腹主动脉缩窄大鼠血浆心房利钠肽(ANP)水平的影响。方法用银夹造成腹主动脉部分狭窄(银夹内径0.7 mm)方法制作腹主动脉缩窄模型,手术4周后,模型组和假手术组灌胃双蒸水,卡托普利组灌胃卡托普利注射液,连续灌胃4周后计算左室心肌质量指数(LVM I),胶原染色观察心肌病理形态,放射免疫法测定血浆ANP水平。结果左室心肌胶原染色显示模型组有大量鲜红色胶原纤维,较假手术组有明显改变,卡托普利组见少量鲜红色胶原纤维存在;模型组LVM I及血浆ANP水平较假手术组显著升高(P均0.01),卡托普利组与假手术组无显著性差异。结论ANP与大鼠腹主动脉缩窄致心肌纤维化相关,卡托普利可能通过影响ANP而抑制心肌纤维化进程。
|
| 关 键 词： | 心肌纤维化 心房利钠肽 放射免疫法 腹主动脉缩窄法 卡托普利 |
Effects of captopril on plasma level of atrial natriuretic peptide in rats with abdominal aortic coarctation |
| |
| Dong Xiaolei,Zhao Zhiming,Jiao Dongdong,Shen Siyu,Zhao Lingjie. Effects of captopril on plasma level of atrial natriuretic peptide in rats with abdominal aortic coarctation[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2010, 19(16): 1969-1970,2035 |
| |
| Authors: | Dong Xiaolei Zhao Zhiming Jiao Dongdong Shen Siyu Zhao Lingjie |
| |
| Affiliation: | Dong Xiaolei,Zhao Zhiming,Jiao Dongdong,Shen Siyu,Zhao Lingjie(Nanjing General Hospital of Nanjing Military Comm,,Nanjing 210002,Jiangsu,China) |
| |
| Abstract: | Objective It is to observe the effects of captopril on the level of plasma atrial natriuretic peptide(ANP) in rats with abdominal aortic coarctation.Methods Abdominal aortic coarctation rat model was established by partially banding abdominal aorta with silver clip(inside diameter 0.7 mm).In 4 weeks after operation,model group and sham operation group was given double distilled water by intragastric administration,and captopril group was given captopril injection by intragastric administration.After 4 weeks... |
| |
| Keywords: | myocardial fibrosis atrial natriuretic peptide radioimmunoassay abdominal aortic coarctation captopril |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
