| Binswanger病患者脑白质疏松的磁共振波谱分析 |
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| 引用本文： | 郭生龙,张虹,王秋莲,李伟,陈岩,宋允章. Binswanger病患者脑白质疏松的磁共振波谱分析[J]. 陕西医学杂志, 2012, 41(10): 1310-1312 |
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| 作者姓名： | 郭生龙 张虹 王秋莲 李伟 陈岩 宋允章 |
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| 作者单位： | 郭生龙 (陕西省人民医院神经内科,西安,710068) ； 张虹 (陕西省人民医院神经内科,西安,710068) ； 王秋莲 (陕西省人民医院神经内科,西安,710068) ； 李伟 (陕西省人民医院神经内科,西安,710068) ； 陈岩 (陕西省人民医院神经内科,西安,710068) ； 宋允章 (陕西省人民医院神经内科,西安,710068) ； |
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| 基金项目： | 陕西省科学技术研究发展计划 |
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| 摘 要： | 目的:运用磁共振波谱(MRS)分析Binswanger病患者脑白质的特征和变化规律。方法:选择61例Binswanger病患者、脑白质疏松症患者53例及正常对照者41例进行双侧侧脑室体旁白质的MRS检查,测定N-乙酰天门冬氨酸(NAA)、肌酸(Cr)及胆碱(Cho)峰的浓度,并计算NAA/Cr及Cho/Cr值。结果:Binswanger病组与正常对照组双侧侧脑室体旁白质的NAA/Cr及Cho/Cr值的比较有统计学差异(P<0.05);Binswanger病组与脑白质疏松症组双侧侧脑室体旁白质的NAA/Cr及Cho/Cr值的比较有统计学差异(P<0.05);Cho/Cr值与白质疏松程度呈正相关(P<0.05)。结论:测定脑白质的NAA/Cr及Cho/Cr值是早期诊断Binswanger病的有效指标。
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| 关 键 词： | 痴呆,血管性 脑白质疏松症 磁共振波谱学 |
Magnetic resonance spectroscopy study of leukoaraiosis in patients with Binswanger disease |
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| Affiliation: | Guo Shenglong Zhang Hong Wang Qiulian et al Department of Neurology,the Shaanxi Provincial People’ Hospital(Xi’an 710068) |
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| Abstract: | Objective:To study the feature and viability of MR spectroscopy of brain white matter in patients with Binswanger.Methods:61 patients with Binswanger disease,53 patients with leukoaraiosis and 41 normal people were selected to be examined by magnetic resonance spectroscopy(MRS).The concentrations of N-acetylaspartate(NAA),Choline(Cho),Creatine(Cr) were measured in Lateral ventricle body side white matter and the ratio of NAA/Cr and Cho/Cr were calculated.Results:There was significant difference in NAA/Cr and Cho/Cr between Binswanger disease-related leukoaraiosis group and normal people group(P<0.05);There was significant difference in NAA/Cr and Cho/Cr between Binswanger disease-related leukoaraiosis group and leukoaraiosis group(P<0.05);Cho/Cr value was positively correlated with the degree of leukoaraiosis.Conclusion:The ratio of NAA/Cr and Cho/C r in brain white matter is valuable index in the early diagnoise of Binswanger disease. |
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| Keywords: | Dementia vascular Leukoaraiosis Magnetic resonance spectroscopy |
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