牛磺酸作为乙肝疫苗佐剂的效果评价

目的进一步探讨牛磺酸作为佐剂在乙肝疫苗接种中的作用。方法将403名2～5岁学龄前儿童随机分为A、B两组。A组研究对象191人,接种乙肝疫苗＋口服安慰剂;B组研究对象212人,接种乙肝疫苗＋口服牛磺酸佐剂;接种完成后30天采血检测。结果A组接种后有88.5%（169/191）的儿童抗-HBs滴度≥10IU/L;B组则有95.8%（203/212）的儿童抗-HBs滴度≥10IU/L,两者差异有统计学意义（χ^2=4.83,P〈0.05）。且B组儿童抗体平均滴度（173.47IU/L）高于A组（132.47IU/L）,差异有统计学意义（t=2.93,P〈0.05）。结论牛磺酸佐剂能显著提高2～5岁儿童乙肝疫苗接种成功率和机体的抗-HBs水平。

New Progress in the Developments of Taurine as Adjuvants for Hepatitis B Vaccine

OBJECTIVE To further study the effect of taurine as an adjuvant for hepatitis B vaccine. METHODS 403 pre-school children who were 2～5 years old were randomly divided into A and B groups. There were 191 persons in group A and 212 persons in group B, group A were vaccinated hepatitis B vaccine and added placebo, group B were vaccinated hepatitis B vaccine and added taurine. Blood was taken for testing after 30 days. RESULTS There were 88.5%（169/191） of children in group A whose anti-HBs titer beyond 10 IU/L after vaccination, and group B was 95.8%（203 / 212）, the difference was statistically significant（χ2=4.83, P〈0.05）. And the average antibody titer of group B（173.47 IU/L） was higher than group A （132.47 IU/L）,the difference was statistically significant（t=2.93, P〈0.05）. CONCLUSION It confirmed that taurine could significantly improve the success rate and the level of anti-HBs of hepatitis B in 2～5 years children .