Evaluation of dengue IgM detection tests using sera from patients with autoimmune diseases |
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| Authors: | Takasaki Tomohiko Nawa Masaru Yamada Ken Ichiro Harada Makoto Takeda Akira Kurane Ichiro |
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| Institution: | Department of Virology 1, Laboratory of Neurovirology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, 162-8640, Tokyo, Japan. takasaki@nih.go.jp |
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| Abstract: | Three commercial dengue IgM test kits and 'in-house' IgM-capture enzyme-linked immunosorbent assay (ELISA) were examined for false positive reactions, using 49 serum samples from patients with autoimmune diseases. All the samples were found to be negative by the 'in-house' IgM-capture ELISA. Five samples were determined to be positive by the immunochromatographic test and three of the five samples were also found positive by one commercial IgM-capture ELISA kit. These results suggest that a possibility of false positive reaction should be considered when serum samples from autoimmune disease patients are tested for dengue IgM by some commercial dengue IgM test kits. |
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