胆结石患者的性激素,血脂,血糖,胰岛素及一氧化氮的改变及临床意义

本文测定了４０例的男女胆结石患者各２０例男女正常人的雌激素（Ｅ２）、睾丸酮（Ｔ）、总胆固醇（ＴＣ）、甘油三脂（ＴＧ）、血糖（ＢＧ）、胰岛素（ＩＳ）、一氧化氮（ＮＯ）。结果显示，男女胆结石患者的Ｅ２，ＴＣ，ＴＧ，ＢＧ，ＩＳ，ＮＯ均显著高于各男女正常对比组，Ｔ均低于各正常对照组，Ｅ２与血脂，ＢＧ，ＩＳ，ＮＯ正相关，Ｔ与ＮＯ负相关，提示高Ｅ２血症、低Ｔ血症通过影响血脂，ＢＧ代谢及胆囊平滑肌松弛致胆石的形

The Clinical Significance of Changes of Plasma Levels of Sex Hormones,Lipid,Glucose,Insulin and Nitric Oxide in Patients With Gallstones

The levelis of plasma estrogen(E2),etstosterone (T),total cholesterol (TC),triglyceride (TG),glucose (BG),insulin(IS) and nitric oxide(NO) were determined in 40 male and 40 female patients with gallstones and 20 male and 20 female normal subjects. The results showed that the E2 TC TG BG IS and NO in both male and female patients were significantly higher than those in nornmal subjects. and T was significantly lower than that in normal subjents.The E2 was positively correlated with TC TG BG IS and NO,T was negatively correlated with NO. The results indicate that, through effecting on metabolism of blood lipid and glucose as well as on relaxation of gallbladder muscle,hyperestrogenemia and hypotestostronemia lead the formation of gallstones. In view of the fact tha there exists we suggest that replacement therapy of estrogen is inadvisable for them.