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Association of complement allotype C4B2 with anterior uveitis |
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| Authors: | Denis Wakefield Rachael Buckley John Golding Peter McCluskey David Abi-Hanna John Charlesworth and Bruce Pussell |
| Institution: | a From the Laboratory of Ocular Immunology, School of Pathology, University of New South Wales, Australia b the Departments of Immunology and Nephrology, Prince Henry Hospital, Sydney, Australia |
| Abstract: | We have studied allotypes of the fourth component of complement (C4) in 44 patients with inflammatory eye disease in order to define genetic susceptibility factors further. Twenty-six patients had uveitis (18 had anterior uveitis) and 18 patients had retinal vasculitis. There was an increased incidence of the C4B2 allotype in patients with anterior uveitis (pc < 0.002), especially in HLA B27 positive males. In contrast, there was no increased incidence of specific allotypes in patients with posterior uveitis or retinal vasculitis. This genetic association may form part of a disease susceptibility supratype in patients with anterior uveitis. |
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