| 表皮生长因子在食蟹猴睾丸不同发育阶段表达的研究 |
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| 引用本文： | 宋卫儒,梁季鸿,梁世坤,朱春晖,张迅,韦国强.表皮生长因子在食蟹猴睾丸不同发育阶段表达的研究[J].山东医药,2010,50(48):32-33,F0003. |
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| 作者姓名： | 宋卫儒 梁季鸿 梁世坤 朱春晖 张迅 韦国强 |
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| 作者单位： | 广西医科大学第一附属医院,南宁,530021 |
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| 基金项目： | 广西"新世纪十百千人才工程"资助项目 |
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| 摘 要： | 目的观察表皮生长因子（EGF）在出生后食蟹猴睾丸发育成熟过程中的表达特征,探讨其在睾丸发育成熟中的作用。方法用免疫组化技术检测食蟹猴从新生猴期至成年猴期不同发育阶段睾丸EGF的表达情况。结果 32只食蟹猴睾丸均表达EGF。EGF主要表达于食蟹猴曲细精管内的精原细胞及一些间质细胞的胞质中,偶见表达于支持细胞胞质。各发育阶段睾丸精原细胞EGF阳性率存在差异（P〈0.01）,以新生猴期最低,童猴后期最高。结论 EGF在食蟹猴睾丸不同发育阶段的表达差异,提示EGF对睾丸的形态发育及功能起调节作用。
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| 关 键 词： | 表皮生长因子 睾丸发育 食蟹猴 |
Expression of epidermal growth factor during the course of testicular development in cynomolgus monkey |
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| SONG Wei-ru,LIANG Ji-hong,LIANG Shi-kun,ZHU Chun-hui,ZHANG Xun,WEI Guo-qiang.Expression of epidermal growth factor during the course of testicular development in cynomolgus monkey[J].Shandong Medical Journal,2010,50(48):32-33,F0003. |
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| Authors: | SONG Wei-ru LIANG Ji-hong LIANG Shi-kun ZHU Chun-hui ZHANG Xun WEI Guo-qiang |
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| Institution: | (The First Affiliated Hospital,Guangxi Medical University,Nanning 530021,P.R.China) |
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| Abstract: | Objective To investigate the expression and effect of epidermal growth factor（EGF） during the course of testicular development of cynomolgus monkey.Methods EGF expression was dectected by using immunohistochemistry method.Results EGF was expressed in cynomolgus monkey testis tissue during different stages of postnatal development,which was mainly located in the cytoplasm of spermatogonia and a few leydig cells,occasionally in sertoli cells.There was significant difference in the ratio of EGF-positive cells in different development stages.Conclusion EGF may play a role in morphological development and function of testis of cynomolgus monkey. |
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| Keywords: | epidermal growth factor testicular development cynomolgus monkey |
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