血清同型半胱氨酸检测的临床意义回顾分析

为探讨血清同型半胱氨酸(THCY)检测的临床意义,回顾性分析173例心脑血管疾病或糖尿病患者和31名正常人血清THCY水平与其Folate,VB12,Glu,CH,Tg,ApoA,ApoB,HDL-CH,LDL-CH水平及所患疾病的关系。结果表明,血清THCY与Folate,VB12浓度呈负相关,与Glu,CH,Tg,ApoA,ApoB,HDL-CH,LDL-CH无明显的相关性。动脉硬化性心血管疾病患者及糖尿病患者的血清THCY浓度明显高于对照组。血清THCY是动脉硬化性心血管疾病及糖尿病的危险因子。Folate,VB12补充疗法可降低血清THCY,可能成为动脉硬化性心血管疾病及糖尿病患者高血THCY血症的治疗方案。

The Retrospective Study of the Clinical Significance of Serum Homocysteine

In order to assess the clinical significance of serum homocysteine,the relationship between serum levels of homocysteine and Folate,VB12,Glu,CH,Tg,ApoA,ApoB,HDL-CH,LDL-CH in 173 patients with cardiovascular disease or diabetes and 31 normal controls was studied retrospectively.The results showed that the serum homocysteine was negatively correlated to the serum levels of Folate and VB12.There was no significant correlation between serum homocysteine and serum levels of Glu,CH,Tg,ApoA,ApoB,HDL-CH and LDL-CH.The serum levels of homocysteine in patients with atheromatous diseases or diabetes were higher than those in control group.The serum homocysteine level is a risk factor of atheromatous diseases.The treatment with Folate and VB12 could reduce the serum level of homocysteine.This might be a therapeutic method for hyperhomocystinemia in patients with atheromatous diseases or diabetes.