湿热环境对辐射损伤动物骨髓和脾脏的影响

目的研究湿热环境对辐射损伤动物骨髓和脾脏的影响。方法将实验动物分为室温组和湿热环境组，两组小鼠首先分别给予6．5Gyγ射线一次全身均匀照射，然后室温组立即置于室温环境中，湿热环境组则先接受湿热环境作用1h，再置于室温环境中。照后1、3、5、9、15d，分别取两组小鼠的骨髓和脾脏，获取骨髓有核细胞(BMC)数、骨髓细胞DNA、脾／体质量比实验指标。结果湿热环境作用组小鼠和室温组小鼠相比，BMC、骨髓细胞DNA及脾／体质量比指标下降。结论湿热环境加重辐射损伤动物骨髓和脾脏的损伤。

Effect of hot and humid environment on bone marrow and spleen of mice exposed to gamma irradiation]

OBJECTIVE: To study the effect of hot and humid environment (HHE) on the bone marrow and spleen in mouse exposed to gamma irradiation. METHODS: After exposure to gamma irradiation at the dosage of 6.5 Gy, the mice were subjected to treatment in HHE for 1 h or at room temperature (RT) respectively. After exposure to HHE, the mice in HHE group were kept at RT. The bone marrow and spleen of the mice in both RT and HHE groups were examined at 1, 3, 5, 9 and 15 days after irradiation for bone marrow cellularity, DNA content in the bone marrow cells, and spleen/body weight ratio. RESULTS: Compared with the RT group, mice in the HEE group showed aggravation of decreases in bone marrow cells, DNA content and spleen/body weight ratio. CONCLUSIONS: HHE aggravates radiation injury of the bone marrow and spleen in mice.