紫杉醇支架冠状动脉造影随访结果分析

目的 观察紫杉醇洗脱支架治疗冠心病的临床实际疗效。方法 297例患者接受紫杉醇洗脱支架治疗，均接受了临床随访，134例于支架置入术后5-15个月行冠状动脉造影随访。结果 冠状动脉造影随访时，晚期管腔丢失支架内显著高于支架近端边缘及支架远端边缘（分别为0.37、0.18和0.12mm），再狭窄率为10．4％，以支架内弥漫性狭窄为主，再血管化率为6．7％。1例患者于支架置入后4个月发生猝死，发生率为0．34％。1例于支架置入后5天发生支架内亚急性血栓形成，发生率0．34％。晚期血栓形成2例（术后12-24个月），主要心血管不良事件发生率1．35％。结论 紫杉醇药物洗脱支架对复杂冠脉病变有较好的疗效，能显著降低支架后再狭窄率及靶血管的再血管化率。

Angiographic follow-up study of the effect after Taxus DES implantation in coronary artery disease patients

Objective To evaluate the angiographic effect in patients treated with Taxus DES implantation in clinical practice. Methods Two hundred and ninty-seven patients were treated with Taxus DES implantation and 134 patients underwent angiographic follow-up from 5 to 15 months. Results Angiographic follow-up the in-stent late loss was higher than pro-in-lesion and dis-in lesion late lumen loss(0.37 vs 0.18 vs 0.12mm,P<0.05). There were 14 case of restenosis in stent (10.4%) and 7 of 14cases were diffuse restenosis in stents (50%). Target lesion revascularization was performed in 6 cases (6.7%). One patient died suddenly at 5th day after the procedure. The rate of sudden death was 0.34%.One patient occurred subacute thrombosis in hospital (0.34%) and two late thrombosis occured in 12 and 24 months after operation (0.68%). The rate of the incidence of major adverse cardiac events was 1.35%. Conclusion Unrestricted utilization of Taxus DES in daily practice is effective in reducing both restennosis and revascularization.