检测血浆纤维蛋白原水平及肺弥散功能变化对COPD患者的临床意义

目的检测血浆纤维蛋白原（Fbg）平及肺弥散功能变化情况对慢性阻塞性肺疾病（COPD）患者诊治的临床意义。方法比较分析测定未合并肺心病组、合并肺心病组的COPD患者均于急性发作期及稳定期各测定1次Fbg、肺一氧化碳弥散量（DLco）水平,与对照组比较。结果未合并肺心病组和合并肺心痛组急性发作期与稳定期的Fbg、DLco水平与对照组比较,差异均有统计学意义（t分别=3．23、3．08、4．72、3．13、4．35、3．52、6．24、3．20,P均〈0．05）;合并肺心病组患者在急性发作期及稳定期Fbg、DLco水平与未合并肺心痛组比较,差异均有统计学意义（t分别=3.22、3．20、3．58、3．02,P均〈0．05）;未合并肺心病组和合并肺心病组患者在急性发作期Fbg水平分别高于稳定期,差异均有统计学意义（t分别：2．57、2．61,P均〈0．05）,而DLco水平则分别低于稳定期．差异有统计学意义（t分别=3．22、4．07,P均〈0．05）。结论血浆Fbg在COPD继发性肺动脉高压及血栓形成过程中发挥着一定的作用．

Clinical significance of plasma fibrinogen and lung diffusing capacity in patients with chronic obstructive pulmonary disease

Objective To evaluate plasma fibrinogen （Fbg） and diffusion of lung in patients with chronic obstructive pulmonary disease. Methods Fbg and diffusing capacity of the lung for carbon monoxide （DLco） were detected in stable and exacerbation stage in 60 COPD patients including 32 with pulmonary heart disease （PHD） and 28 without. Twenty five healthy subjects were measured only once as control group. Results The differences of Fbg and DLco levels between the COPD patients and control group had statistic significance （t=3.23,3.08,4.72,3.13,4.35, 3.52,6.24,3.20,P〈0.05）. The differences of the Fbg and DLco levels between the patients complicated with PHD and without had statistic significance （t=3.22,3.20,3.58,3.02,P〈0.05）. The Fbg level of the COPD patients in exacerbation was higher than that in stable phase （t=2.57,2.61,P〈0.05）; the DLco level of the COPD patients in exacerbation was lower than that in stable phase （t=3.22,4.07,P〈0.05）. Conclusion Elevated Fbg was associated with secondary pulmonary hypertension and thrombogenesis in COPD patients.