| 基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1、增殖细胞核抗原在病理性瘢痕中的表达 |
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| 引用本文： | 郭丽丽,刘林嶓,陈言汤.基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1、增殖细胞核抗原在病理性瘢痕中的表达[J].中国美容医学,2005,14(5):544-546. |
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| 作者姓名： | 郭丽丽 刘林嶓 陈言汤 |
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| 作者单位： | 郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,河南省,郑州市,450052 |
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| 摘 要： | 目的：研究基质金属蛋白酶-1（MMP-1）、金属蛋白酶组织抑制剂-1（TIMP-1）、增殖细胞核抗原（PCNA）在病理性瘢痕中的表达及意义.方法：对58例病理性瘢痕手术切除标本采用免疫组化方法.结果：MMP-1、TIMP-1、PCNA在病理性瘢痕中呈阳性表达.结论：病理性瘢痕中细外基质合成增加为成纤维细胞过度增殖所致;病理性瘢痕形成与MMP-1、TIMP-1相互作用失衡有关.
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| 关 键 词： | 增生性瘢痕 瘢痕疙瘩 基质金属蛋白酶-1 金属蛋白酶组织抑制剂-1 增殖细胞核抗原 |
| 文章编号： | 1008-6455（2005）05-0544-03 |
| 收稿时间： | 2005-04-18 |
| 修稿时间： | 2005-06-10 |
Expression of Matrix Metalloproteinase-1,Tissue luhibitor of Metall proteinase-1,Proliferating cell Nuclear antigen in abnorrnal scar |
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| GUO Li-li,LIU Lin-bo,CHEN Yan-tang.Expression of Matrix Metalloproteinase-1,Tissue luhibitor of Metall proteinase-1,Proliferating cell Nuclear antigen in abnorrnal scar[J].Chinese Journal of Aesthetic Medicine,2005,14(5):544-546. |
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| Authors: | GUO Li-li LIU Lin-bo CHEN Yan-tang |
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| Abstract: | Objective To study the significance of expression of Matrix Metalloproteinase-1(MMP-1) ,Tissue Inhibitor of Metalloproteinase-1(TIMP-1) and Proliferating cell nuclear antigen (PCNA) in abnormal scar. Methods The tissue of abnormal scar was obtained from 58 patients who were underwent surgery . The polyclone antibodies of anti-MMP-1,anti-TIMP-1 and the single-clone antibodies of anti-PCNA were used to performed immunohistochemical staining(SABC method ). Results There are obvious difference about the positive rate of MMP-1,TIMP-1 and PCNA among abnormal scar and normotrophic scar,normal skin respectively(P<0.05). Conclusion The mechanism of abnormal scar formation is correlate with the imbalance of regulation among MMP-1,TIMP-1. |
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| Keywords: | hypertrophic scar keloid matrix matalloproteinase-1 tissue inhibitor of metalloproteinase-1 proliferat-ing cell nuclear antigen |
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