| 子宫内膜层粘连蛋白与Norplant致子宫异常出血的相关性研究 |
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| 引用本文： | 史小林,韩学军,翁静. 子宫内膜层粘连蛋白与Norplant致子宫异常出血的相关性研究[J]. 中华妇产科杂志, 2000, 35(3): 169-171 |
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| 作者姓名： | 史小林 韩学军 翁静 |
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| 作者单位： | [1]首都医科大学生殖医学研究中心 [2]首都医科大学附属红十字朝阳医院妇产科 |
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| 基金项目： | 北京市自然科学基金资助!(编号:7982015) |
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| 摘 要： | 目的 探讨层粘连蛋白（ＬＮ）与Ｎｏｒｐｌａｎｔ致子宫不规则出血的关系。方法 对正常增殖期妇女子宫内膜（６例）和埋植Ｎｏｒｌｐａｎｔ半年、１年及２年以上月经规律及有子宫不规则出血妇女（各６例，共３６例）的子宫内膜进行组织学观察，并用显微分光光度计对用免疫组织化学方法显示的子宫内膜ＬＮ进行定量分析。结果 使用Ｎｏｒｌｐａｎｔ妇女的子宫内膜，（１）均无典型的周期特点，腺体明显减少，有腺体发育不同步现象；
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| 关 键 词： | 层粘连蛋白 子宫不规则出血 Norplant |
| 修稿时间： | 1999-03-24 |
Study on Relationship between Endometrium Laminin Expression and Irregular Uterine Bleeding in Norplant Users |
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| SHI Xiaolin ,HAN Xuejun,WENG Jing,et al.. Study on Relationship between Endometrium Laminin Expression and Irregular Uterine Bleeding in Norplant Users[J]. Chinese Journal of Obstetrics and Gynecology, 2000, 35(3): 169-171 |
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| Authors: | SHI Xiaolin HAN Xuejun WENG Jing et al. |
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| Affiliation: | Department of Reproductive Medicine, Capital University of Medical Sciences, Beijing 100054, China. |
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| Abstract: | OBJECTIVE: To investigate the relationship between endometrium laminin (LN) expression and irregular uterine bleeding in Norplant users. METHODS: Eighteen endomerium samples obtained during day 10-14th from Norlant users for 1/2, 1 or > 2 years respectively with irregular bleeding were studied morphologically and immunohistochemically for LN expression. Six normal proliferative endometria and 18 connterpacts with regular bleeding were used as control. RESULTS: In Norplant users, endometrial glands decreased in numbers and asynchromized in appearance. The LN expression on basal lamina of glandular epithelium and vascular endothelium was lower in those with irregular bleeding as compared with regular bleeders (P < 0.05). CONCLUSION: The decline of LN expression may related to irregular bleeding in Norplant users. |
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| Keywords: | Levonorgestrel Laminin Endometrium ?Metrorrhagia |
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