High-dose cytosine arabinoside and mitoxantrone in previously-treated acute leukemia patients |
| |
Authors: | C Lejeune N Tubiana J A Gastaut D Maraninchi B Richard M C Launay D Sainty G Sebahoun Y Carcassonne |
| |
Affiliation: | Institut J. Paoli-I. Calmettes, Marseille, France. |
| |
Abstract: | 35 patients with refractory or relapsed acute leukemia received salvage chemotherapy using high-dose cytosine arabinoside 2 g/m2 intravenously for 3 hours every 12 h, in 8 doses, followed by continuous infusion of mitoxantrone 12 mg/m2/day for 2 d. 9 patients had acute myeloblastic leukemia (AML), (4 relapsed, 5 refractory), 20 had acute lymphoblastic leukemia (ALL) (11 relapsed, 9 refractory) and 6 had chronic myelogenous leukemia (CML) in the blastic phase (BP). 4 out of 9 AML and 16 out of 20 ALL achieved complete remission. Median survival was 6 months for all patients and 10 months for responders. A short (1.5 months) chronic phase was achieved in 3 patients with CML. The main toxic effect was hematologic. A pharmacokinetic study was performed on mitoxantrone. No correlation was found with clinical response. The combination of mitoxantrone and ara-C is an effective antileukemic regimen, especially in ALL. |
| |
Keywords: | ara-C mitoxantrone acute leukemia |
|
|