| 鱼藤酮对大鼠尾核及血浆中NOS活性和NO含量的影响 |
| |
| 引用本文： | 李云鹏,董兆君,杨书.鱼藤酮对大鼠尾核及血浆中NOS活性和NO含量的影响[J].第三军医大学学报,2003,25(13):1131-1133. |
| |
| 作者姓名： | 李云鹏 董兆君 杨书 |
| |
| 作者单位： | 1. 第三军医大学预防医学系军事毒理学教研室,重庆,400038
2. 第三军医大学成都军医学院军事医学教研室,成都,610083 |
| |
| 基金项目： | 重庆市科学研究基金课题 ( 2 0 0 0 ) |
| |
| 摘 要： | 目的 研究鱼藤酮慢性中毒大鼠尾核脑区及血浆的一氧化氮（NO）含量和一氧化氮合成酶（NOS）活性的变化规律。方法 Wistar大鼠每日皮下注射0.335、0.670、1.005mg/kg鱼藤酮共90d。于30、60、90d处死动物，分离血浆和尾核脑组织，以生化方法测定NOS活性和NO含量。结果 在鱼藤酮中毒规律脑组织中NOS活性和NO含量增加，增加程度因中毒剂量的提高而升高、随中毒时间的延长而升高。结论 长期接触鱼藤酮导致血浆和尾核脑组织NOS活性和NO含量升高。
|
| 关 键 词： | 鱼藤酮 一氧化氮 一氧化氮合成酶 尾核 血浆 大鼠 |
| 文章编号： | 1000-5404(2003)13-1131-03 |
| 修稿时间： | 2003年3月12日 |
Effects of rotenone on NOS activity and NO concentration in caudatum and plasma in rats |
| |
| LI Yun peng,DONG Zhao jun,YANG Shu.Effects of rotenone on NOS activity and NO concentration in caudatum and plasma in rats[J].Acta Academiae Medicinae Militaris Tertiae,2003,25(13):1131-1133. |
| |
| Authors: | LI Yun peng DONG Zhao jun YANG Shu |
| |
| Abstract: | Objective To observe the rotenone induced changes of nitric oxide (NO) concentration and nitric oxide synthase (NOS) activity in rat caudate nuclei and blood plasma. Methods Wistar rats were daily administrated with rotenone at the doses of 0.335, 0.670 and 1.005 mg/kg(sc). Animals were sacrificed on days 30, 60 and 90. The NO concentration and the NOS activity in the caudate nuclei and blood plasma were determined by biochemical methods. Results At each time point of days 30, 60 and 90, rotenone induced significant increases in NO concentration and NOS activity in both the caudate nuclei and blood plasma in dose and time dependent manners. Conclusion Long term exposure to rotenone leads to the increase of nitric oxide and nitric oxide synthase in brain tissues and blood plasma in rat. |
| |
| Keywords: | rotenone nitric oxide nitric oxide synthase caudatum plasma |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
