Effects of electroacupuncture on the ability of learning and memory in rats with ischemia-reperfusion injury |
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| Authors: | Lin-bao Ge Cheng Fang Ming-shu Xu Jia Xu Chang-zhi Li |
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| Institution: | (1) Shanghai Research Center for Acupuncture and Meridian, Shanghai, 201203, P. R. China;(2) Shanghai Qigong Institute, Shanghai, 200030, P. R. China;(3) Yueyang Hospital of Integrative Chinese & Western Meidcine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, P. R. China;(4) Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, P. R. China |
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| Abstract: | Objective To observe the effects of pretreatment and treatment with electroacupuncture on the ability of learning and memory in rats
with ischemia-reperfusion injury, and to provide the research basis for preventing and treating the disorder of learning and
memory in patients with apoplectic sequelae.
Methods Seventy-two SD rats, clean class, were randomly divided into sham operation group, model group, pretreatment group, and treatment
group. The step-through latency and number of errors, nerve injury score, and the number of cholinoceptor in the affected
hippocampus were recorded to analyze the effects of pretreatment and treatment with electroacupuncture on the ability of learning
and memory in rats with ischemia-reperfusion injury.
Results 1) The rats with ischemia had various signs of nerve injury. Compared with that in the sham operation rats, the nerve injury
score in the model rats was lower, the step-through latency and number of errors were increased, and the content of special
mAchR was decreased (P<0.05); 2) Electroacupuncture could decrease the nerve injury score of the model rats. Compared with those in the model group,
the step-through latency and number of errors all had significant difference in the pretreatment and treatment groups (P<0.05); 3) Compared with that in the model group, the content of mAchR was increased in the pretreatment group (P<0.05), and increased a little in the treatment group.
Conclusion Pretreatment and treatment with electroacupuncture can prolong step-through latency, and induce number of errors. Electroacupuncture
pretreatment can increase the content of mAchR induced by ischemia-reperfusion injury, to improve the ability of learning
and memory. Electroacupuncture pretreatment plays an important role in preventing the disorder of learning and memory in patients
with ischemic cerebrovascular disease.
Author: GE Lin-bao (1951–), male, research fellow, engaging in the research of acupuncture treating ischemic apoplexy |
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| Keywords: | Stroke Brain lschemia Reperfusion Injury Electroacupuncture Receptors Cholinergic Rats |
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