Preliminary Results of Authentic Recombinant Somatropin Treatment in Human Growth Hormone Deficient Children. French Collaborative Study |
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Authors: | R. RAPPAPORT |
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Affiliation: | Department of Paediatrics, Hôpital des Enfants Malades, Paris, France |
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Abstract: | A total of 50 children with hGH deficiency have been enrolled in a multicentre open trial of recombinant somatropin in France. Recombinant somatropin, 0.2 IU/kg s.c, was administered 3 times/week (0.6 IU/kg/week). Results are available after 3 months'treatment for 24 of the patients (11 prepubertal, 13 pubertal). The mean growth rate increased from 3.8 ± 1.5 cm/year to 9.9 ± 3.6 cm/year. Only one child developed anti-hGH antibodies with a very low binding capacity of 0.02 mg/litre; adverse events were uncommon and probably unrelated to treatment. |
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Keywords: | Recombinant somatropin height velocity anti-hGH antibody |
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