MRI 3D-VIBE序列全肝灌注应用探讨

目的：探讨磁共振三维客积式内插法屏气检查（3D-VIBE）序列对人全肝灌注的可行性及其临床应用价值。方法：30例健康志愿者行常规MRI T1WI、T2WI轴面及true-FISP冠状面扫描后，采用经改良的3D-VIBE序列行全肝灌注扫描，然后在肝左、右叶、腹主动脉及门静脉区分别选择兴趣区（ROI），测量其在注射Gd—DTPA后不同灌注时间及延迟期的信号强度值，最后绘制时间-浓度曲线。结果：每个志愿者分别得到4条关于肝左、右叶、腹主动脉及门静脉的时间-浓度曲线。Od—DTPA在肝左、右叶、腹主动脉和门静脉的动态浓度范围分别为0～0．6mmol／l、0～0．6mmol／l、0～1．7mmol／l和0～1．0mmol／l。肝左、右叶及门静脉时间-浓度曲线较柔和，缓慢达峰并缓慢下降；腹主动脉时间-浓度曲线有2个峰值，且达峰时间快。结论：应用改良的3D-VIBE序列行全肝灌注的技术切实可行，能从中获得时间-浓度曲线，使肝血流灌注参数量化，对评估肝血流灌注异常具有重要临床意义。

Application Study of MR 3-dimensional Volumetric Interpolated Breath-hold Examination in Whole Liver Perfusion Imaging

Objective： To investigate the feasibility and clinical application of 3-dimensional volumetric interpolated breath-hold examination （3D VIBE） in MR whole liver perfusion imaging. Methods： 30 healthy volunteers undertook conventional MRI including axial plane with spin echo T1W,T2 W,coronal plane with true-FISP and modified 3D-VIBE whole liver perfusion sequences. Selected tke regions of interest （ROD in left hepatic lobe （LHL） .right hepatic lobe （RHL） .abdominal aorta （AO） and portal vein ,OPV） ,the signal intensitise of ROIs of different phases and delayed phase after injection of Gd-DTPA were measured respectively,time-concentration curves were drawn. Resules：Four time-concentration curves of LHL.RHL.AO and PV respectively were obtained in each of the volunteers. The dynamic concentration of Gd-DTPA were 0-0.6mmol/l.0-0.6mmol/1.0-1. 7mmol/1 and 0-1. 0mmol,/1 in LHL.RHL.AO and PV respectively. The time-concentration curve of LHL.RHL and PV were gentle,showing slowly ascended to peak than slowly descended. The time-concentration curves of AO had two peaks which were reached swiftly. Conclusion：It is feasible to use modified 3D-VIBE in whole liver perfusion imaging. Time-concentration curves and quantified perfusion parameters of liver could be obtained,which are very important in estimating the abnormal perfusion of liver.