我院住院患者抗菌药物应用与革兰阴性杆菌耐药情况分析

目的了解我院2007年细菌耐药性的变化趋势，研究抗菌药物使用与病原菌耐药性的关系。方法通过计算用药频度（DDDs）分析抗菌药物的使用趋势；对临床常见革兰阴性杆菌耐药性监测的资料进行统计分析。结果使用频度前10位的抗菌药物种类包括头孢类、喹诺酮类、青霉素＋酶抑剂、碳青霉烯类等；2年分离革兰阴性菌占57．70％，肠杆菌科病原菌的产ESBLs酶的分离率平均为31．18％。结论广泛使用抗菌药物使细菌耐药性增加，合理使用抗菌药物是降低耐药性和多重耐药性的关键。

The Associativity Analysis of Antibacterials Usage and Drug Resistance in Our Hospital

Objective To study the variation of bacterial drug resistance, the consumption of antibacterials in 2007 in our hospital as well as the relationship between physicians preference in drug choice and the bacterial drug resistance. Methods The use of antibiotics was expressed in DDDs ; Meanwhile, the clinical common gram negative bacilli were isolated and identified and their antibiotic resistance tendency in two years were evaluated. Results The top ten antibiotics in medication frequency were cephamycins,quinolones,penicillins ＋ enzyme inhibitor , carbopenems, etc ; The strains of bacteria were isolated 57.7 % bacteria were gram negative, the average separation of extended spectrum ？ -lactamase （ESBL）were seen in 31.18%. Conclusion The extensive use of antibacterials resuhs in increased drug resistance. It is urgent to conduct epidemiological investigation and to take appropriate measures in control of bacterial resistance.