胃癌及其胃粘膜病变的粘液组织化学和免疫组织化学的研究

对114例不同组织类型的胃癌及其胃粘膜组织，进行了粘液组织化学和癌胚抗原免疫组织化学研究。结果表明：肠上皮化生（肠化）检出率在萎缩性胃炎对照组高于癌组，癌组的肠化检了率非癌组织高于癌旁组织。肠化细胞是成熟性增生，它和不典型增生及癌均未发现有过渡形式。不典型增生偶见细胞癌变，有时也不易和高分化腺癌鉴别。认为肠化是对有害因子刺激的适应性变化，而不典型增生多系癌前病变。癌胚抗原在不同类型的胃癌组织中分布和量的不同除标志着分泌和释放不同外，可能也有助于判断癌的预后。

Histochemical and immunohistochemical studies of gastric carcinoma and pertaining gastric mucosa

114 cases of gastric carcinoma of various types and the gastric mucosa pertaining to the lesions from surgical biopsies were studied with CEA immunohistochemistry and histochemistry. The detectable rate of intestinal metaplasia (IM) of atrophic gastritis of the control group and the gastric mucosa pertaining to carcinomas was higher than that of the cancer group. Heteromorphism, dysplasia, and cancerization were not obtained in these proliferative cells of the IM. There were no transitional forms found between IM and atypical hyperplasia or between IM and carcinoma. Since most of these lesions belong to colonic type of IM and intestinal type of gastric carcinoma, it might be due to a shift of cell differentiation from the well functioning cells to the poorly functioning cells of the colon like glands for adaptation. The CEA positive cells were 60% in the IM of atrophic gastritis, and not all these CEA positive cells possessed a close relation with cancer. Anyhow the extent of CEA positive cells is still possibly a criterion in estimating the prognosis of gastric carcinoma.