Human metapneumovirus and human bocavirus associated with respiratory infection in Apulian population |
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| Authors: | Guido M Quattrocchi M Campa A Zizza A Grima P Romano A De Donno A |
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| Institution: | a Laboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, Faculty of Sciences, University of Salento, Lecce, Italyb Institute of Clinical Physiology, National Research Council, Lecce, Italyc Division of Infectious Diseases, HIV Center, S. Caterina Novella Hospital, Galatina, Lecce, Italyd Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, Faculty of Sciences, University of Salento, Lecce, Italy |
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| Abstract: | We have studied the occurrence of hBoV, hMPV and InfA-B in an Apulian population with respiratory tract infections. During influenza season 2008-2009, 116 oropharingeal swabs were collected from patients affected by Influenza-Like Illness (ILI). The PCR products of hMPV M and HBoV NP-1 genes were sequenced. 78 out of 116 samples were positive for at least one respiratory virus; hBoV was detected in 53, hMPV in 22 and InfA-B in 41 out of 116 swabs. A high rate of hBoV infection in adult (18.9%) and elderly (26.4%) subjects was found. The co-infection rate was higher for hMPV (18/22 cases, 81.8%) compared to hBoV (26/53 cases, 49.1%), and InfA-B (25/41 cases, 61.0%). Co-infections were common in children. hBoV positive samples shared a high level of genetic similarity with the hBoV1 genotype, and hMPV positive samples clustered with A2 subgroup. Our results suggest that hBoV and hMPV play a role in ILI. |
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| Keywords: | Human bocavirus Human metapneumovirus Influenza virus Infection Surveillance |
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