Hepatic arterial buffer response after pediatric living donor liver transplantation: report of a case |
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| Authors: | Sanada Y Mizuta K Urahashi T Ihara Y Wakiya T Okada N Yamada N Egami S Hishikawa S Ushijima K Otomo S Sakamoto K Yasuda Y Kawarasaki H |
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| Affiliation: | aDepartment of Transplant Surgery, Jichi Medical University, Shimotsuke City, Tochigi, Japan;bDepartment of Clinical Pharmacology, Jichi Medical University, Shimotsuke City, Tochigi, Japan;cDepartment of Pharmacy, Jichi Medical University Hospital, Shimotsuke City, Tochigi, Japan;dDepartment of Surgery, Jichi Medical University, Shimotsuke City, Tochigi, Japan |
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| Abstract: | BackgroundExcessive portal pressure at an early stage after living-donor liver transplantation (LDLT) can damage sinusoidal endothelial cells and hepatocytes through shear stress leading to graft failure, or hepatic arterial complications due to low hepatic artery flow from a hepatic arterial buffer response. We encountered a case in which excessive portal vein flow was observed from an early stage after pediatric LDLT. The hepatic artery flow decreased due to a hepatic arterial buffer response.Case reportA 6-month-old boy with biliary atresia showed excessive portal vein flow early after LDLT with a decreasing hepatic artery flow without anastomotic stenosis from postoperative day 3. The PV flow gradually exhibited a decrease at approximately postoperative day 8 and, similtaneously, hepatic artery flow exhibited improvement.ConclusionBecause excessive portal pressure after LDLT is reversible, it has been suggested that it may be possible to prevent the progress of hepatic arterial complications if temporary portal pressure modulation can be performed for cases among the high-risk group for hepatic arterial complications. |
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