Use of a gonadotropin-releasing hormone antagonist for endometrial maturation and synchronization in an ovum recipient

OBJECTIVE: To report the novel use of hMG and the GnRH antagonist for endometrial preparation and synchronization in a woman participating in an ovum donation program who was resistant to endometrial preparation with estrogen replacement. DESIGN: Case report. SETTING: Tertiary fertility center. PATIENT(S): The patient had inadequate endometrial maturation, as determined by pelvic ultrasound (thickness of <5 mm), after estrogen replacement. Ovarian hyperstimulation with hMG and a GnRH antagonist resulted in an endometrial thickness of 7.5 mm. Synchronization with a ovum donor resulted in a delivered twin gestation. INTERVENTION(S): : Late follicular transvaginal ultrasound. MAIN OUTCOME MEASURE(S): Appropriate endometrial maturation and pregnancy. RESULT(S): Appropriate endometrial maturation. CONCLUSION(S): For women with inadequate endometrial maturation with simple estrogen replacement, ovarian hyperstimulation with hMG and a GnRH antagonist can yield appropriate endometrial maturation for pregnancy through ovum donation.