| N-乙酰氨基葡萄糖对应激小鼠巨噬细胞吞噬功能的调节作用 |
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| 引用本文： | 裴轶劲,吴小兰,毛方圆,陈婉燕,刘俊康. N-乙酰氨基葡萄糖对应激小鼠巨噬细胞吞噬功能的调节作用[J]. 第三军医大学学报, 2009, 31(19): 1869-1871 |
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| 作者姓名： | 裴轶劲 吴小兰 毛方圆 陈婉燕 刘俊康 |
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| 作者单位： | 第三军医大学医学检验系暨药学院生物波研究室,重庆,400038;第三军医大学学员旅13队,重庆,400038 |
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| 摘 要： | 目的 探讨N-乙酰氨基葡萄糖(N-Acetyl-D-glucosamine,GlcNAc)对应激小鼠模型腹腔巨噬细胞(peritonealmacrophage,PMψ)吞噬功能的调节作用.方法 以足底电刺激法复制应激小鼠模型,将50只小鼠分为正常对照组、应激模型组、低剂量GlcNAc治疗组、中剂量GlcNAc治疗组和高剂量GlcNAc治疗组,每组10只.采用酵母吞噬法检测PMψ吞噬功能,MTT法检测PMψ能量代谢水平,使用原子力显微镜观察PMψ吞噬酵母的情况.结果 与正常对照组相比,应激模型组PMψ吞噬功能明显下降(P<0.01),能最代谢水平明显下降(P<0.01),而中剂量和高剂量GlcNAc能有效提高巨噬细胞吞噬功能和调节细胞活性.结论 GlcNAc可促进应激小鼠PMψ的吞噬而改善免疫功能.
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| 关 键 词： | 应激 GlcNAc 巨噬细胞 吞噬 免疫 |
Regulation of N-Acetyl-D-glucosamine on macrophages function of stressed mice |
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| PEI Yi-jin,WU Xiao-lan,MAO Fang-yuan,CHEN Wan-yan,LIU Jun-kang. Regulation of N-Acetyl-D-glucosamine on macrophages function of stressed mice[J]. Acta Academiae Medicinae Militaris Tertiae, 2009, 31(19): 1869-1871 |
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| Authors: | PEI Yi-jin WU Xiao-lan MAO Fang-yuan CHEN Wan-yan LIU Jun-kang |
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| Affiliation: | PEI Yi-jin1,WU Xiao-lan1,MAO Fang-yuan2,CHEN Wan-yan2,LIU Jun-kang1(1Bio-wave Research Center,College of Laboratory Medicine,213rd Student Team,Third Military Medical University,Chongqing 400038,China) |
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| Abstract: | Objective To investigate the regulative role of N-Acetyl-D-glucosamine(GlcNAc) on the stressed mice macrophages function.Methods The stressed mice model was established by electric footshock method.The mice were divided into 5 groups:normal control group,stressed mice model group,low dose Glc-NAc treatment group(0.25 ml 15% GlcNAc),medium-dose GlcNAc treatment group(0.5 ml 15% GlcNAc) and high-dose GlcNAc treatment group(1 ml 15% GlcNAc).GlcNAc was intragastrically injected to corresponding mice 2 h before ... |
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| Keywords: | GlcNAc |
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